ArticleWorld journal of gastroenterology2005
Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prognostic Value of Lymph-Node Micrometastases and Isolated Tumour Cells in Gastric Cancer.Cureus · 2026Article
- Deep neural network trained on gigapixel images improves lymph node metastasis detection in clinical settings.Nature communications · 2022Article
- Fast Segmentation of Metastatic Foci in H&E Whole-Slide Images for Breast Cancer Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Lymph Node Micrometastases are Associated with Worse Survival in Patients with Otherwise Node-Negative Hilar Cholangiocarcinoma.Annals of surgical oncology · 2015Article
- Gastric carcinoma: stage migration by immunohistochemically detected lymph node micrometastases.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2015Article
- Lymph node, peritoneal and bone marrow micrometastases in gastric cancer: Their clinical significance.World journal of gastrointestinal oncology · 2012Article
- Clinical implications of immunohistochemically demonstrated lymph node micrometastasis in resectable pancreatic cancer.Journal of Korean medical science · 2011Article
- Sentinel lymph node biopsy in the management of early-stage cervical carcinoma.Gynecologic oncology · 2011Article
- Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer.World journal of gastroenterology · 2009Article
- Analysis of risk factors for the interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy.World journal of gastroenterology · 2008Article
- [Minimal residual tumor in gastrointestinal carcinoma. Relevance to prognosis and oncologic surgical consequences].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2006Review
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5 authors.
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Abstract
aimTo determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer.
methodsHematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and 5 cases indefinite for lymph node metastases. Lymph node metastases were divided into ITCs, micrometastases, or macrometastases, according to the sizes of tumor deposits in largest dimension. ITCs were further classified into four groups according to metastasis pattern.
resultsLymph node metastases were identified by immunostaining in 58 of 280 node-negative cases (20.7%) and were not significantly associated with patient survival (P = 0.3460). After cytokeratin immunostaining, 196 cases were classified as pN1, which consisted of 20 cases with micrometastases detected by immunostaining (pN1mi(i+)), 34 cases with only micrometastases (pN1mi), and 142 cases with pN1 with one or more macrometastases (pN1). Cases with pN1mi and pN1mi(i+) had a significantly better prognosis than the cases with pN1 (P = 0.0037). ITCs were found in 38 of these 58 cases, and could be divided into four groups: 12 cases with only a single cell pattern, 7 cases with multiple individual cells, 5 cases with single small cluster, and 14 cases with multiple small clusters. Among these four groups, cases with ITCs of multiple individual cell pattern showed the worst survival (median survival: 28 mo, P<0.0001).
conclusionBoth size and pattern of lymph node metastases can give prognostic information on the survival of gastric cancer patients.
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