ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2006
Pea3 expression is regulated by FGF signaling in developing retina.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The Role of Pea3 Transcription Factor Subfamily in the Nervous System.Molecular neurobiology · 2025Review
- RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration.Development (Cambridge, England) · 2024Article
- Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development.Open biology · 2022Review
- Transcriptomic profile of Pea3 family members reveal regulatory codes for axon outgrowth and neuronal connection specificity.Scientific reports · 2020Article
- Involvement ofFrontiers in molecular biosciences · 2020Article
- Secretome Screening Reveals Fibroblast Growth Factors as Novel Inhibitors of Viral Replication.Journal of virology · 2018Article
- Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish.PLoS genetics · 2017Article
- Article
- The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development.Mechanisms of development · 2014Article
- Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development.Molecular biology of the cell · 2014Article
- Pea3 transcription factor promotes neurite outgrowth.Frontiers in molecular neuroscience · 2014Article
- Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.Developmental biology · 2013Article
- FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathway.BMC developmental biology · 2009Article
- Birth of ophthalmic trigeminal neurons initiates early in the placodal ectoderm.The Journal of comparative neurology · 2009Article
- Temporal regulation of Ath5 gene expression during eye development.Developmental biology · 2009Article
- ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm.Molecular vision · 2008Article
- Notch signaling regulates regeneration in the avian retina.Developmental biology · 2007Article
- Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells.Developmental biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal ganglion cell differentiation. These results suggest that FGF signaling via MAPK up-regulates transcription factors that in turn control retinal ganglion cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.