ReviewBone marrow transplantation2006
Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter?
Review in Bone marrow transplantation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Critically ill allogenic HSCT patients in the intensive care unit: a systematic review and meta-analysis of prognostic factors of mortality.Bone marrow transplantation · 2018Pooled it
- Outcome of children requiring intensive care following haematopoietic SCT for primary immunodeficiency and other non-malignant disorders.Bone marrow transplantation · 2012Trial
- Safe transfer of pediatric patients from hematopoietic stem cell transplant unit into the pediatric intensive care unit: views of nurses and physicians.Bone marrow transplantation · 2022Article
- Net reclassification improvement with serial biomarkers and bed-sided spirometry to early predict the need of organ support during the early post-transplantation in-hospital stay in allogeneic HCT recipients.Bone marrow transplantation · 2019Article
- Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018Article
- Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis.Bone marrow transplantation · 2016Review
- Risk factors for ICU admission and ICU survival after allogeneic hematopoietic SCT.Bone marrow transplantation · 2014Article
- Hematopoietic cell transplantation-specific comorbidity index predicts inpatient mortality and survival in patients who received allogeneic transplantation admitted to the intensive care unit.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning.British journal of haematology · 2013Article
- The critically-ill pediatric hemato-oncology patient: epidemiology, management, and strategy of transfer to the pediatric intensive care unit.Annals of intensive care · 2012Article
- Impact of critical care outreach on hematopoietic stem cell transplant recipients: a cohort study.Bone marrow transplantation · 2011Article
- The care of critically ill children after hematopoietic SCT: a North American survey.Bone marrow transplantation · 2011Article
- Sequential Organ Failure Assessment predicts the outcome of SCT recipients admitted to intensive care unit.Bone marrow transplantation · 2010Article
- Management of patients transferred to the ICU during the conditioning phase of allogeneic hematopoietic stem cell transplantation.Intensive care medicine · 2009Article
- Predictors of mortality in patients undergoing autologous hematopoietic cell transplantation admitted to the intensive care unit.Bone marrow transplantation · 2009Article
- Outcome and prognostic indicators of patients with hematopoietic stem cell transplants admitted to the intensive care unit.Journal of transplantation · 2009Article
- Acute renal failure after allogeneic myeloablative stem cell transplantation: retrospective analysis of incidence, risk factors and survival.Bone marrow transplantation · 2007Article
- Outcome of adult umbilical cord blood transplant patients admitted to a medical intensive care unit.Bone marrow transplantation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We critically reviewed published English language literature and concluded that from 1998 onward the survival of hematopoietic stem cell transplant (SCT) patients who experienced intensive care unit (ICU) transfer has improved. The factors associated with increased mortality during ICU stay included increased patient age, allogeneic transplant, intubation/mechanical ventilation, multiorgan system failure (MOSF), presumed/documented infection, graft-versus-host disease, and higher APACHE and O-PRISM score at ICU transfer. This encouraging outcome trend reflects evolving advances such as use of recombinant hematopoietic growth factors, use of mobilized blood cells rather than marrow, protective strategies for acute lung injury and early goal-directed therapy for sepsis syndrome. Patient selection bias (which patients were transferred and which were not sent to an ICU) also plays a role in ICU survival rates. New strategies to improve upon SCT patient outcome include use of a scoring system to predict mortality, better therapies for MOSF and integration of ICU components and multispecialist involvement earlier in the clinical course to prevent severe complications such as respiratory failure. SCT recipients comprise a heterogeneous group; to further advance this field, prospective multicenter trials involving larger populations from many centers are needed to reduce the biases of retrospective and single-center reports.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.