ArticleNature immunology2005
Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes.
Article in Nature immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- IL-15 in T-Cell Responses and Immunopathogenesis.Immune network · 2024Review
- The intestinal γδ T cells: functions in the gut and in the distant organs.Frontiers in immunology · 2023Review
- In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity.Cell & bioscience · 2021Review
- Function of γδ T cells in tumor immunology and their application to cancer therapy.Experimental & molecular medicine · 2021Review
- Adoptive cell therapy of patient-derived renal cell carcinoma xenograft model with IL-15-induced γδT cells.Medical oncology (Northwood, London, England) · 2021Article
- The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation ofFrontiers in immunology · 2021Review
- Review
- Review
- Human γδ T-Cell Control of Mucosal Immunity and Inflammation.Frontiers in immunology · 2018Review
- Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Frontiers in immunology · 2018Review
- γδ T cells in homeostasis and host defence of epithelial barrier tissues.Nature reviews. Immunology · 2017Review
- Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8EBioMedicine · 2017Article
- Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.Nature immunology · 2015Article
- Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.Frontiers in immunology · 2015Review
- IL-15: a central regulator of celiac disease immunopathology.Immunological reviews · 2014Review
- Dynamics of the interaction of γδ T cells with their neighbors in vivo.Cellular and molecular life sciences : CMLS · 2011Review
- Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.Journal of virology · 2010Article
- Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Mechanics of T cell receptor gene rearrangement.Current opinion in immunology · 2009Review
- Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.American journal of immunology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexity has been widely disseminated. Here we present data showing that the generation of the restricted TCR variable gamma-region gene repertoire of intestinal intraepithelial lymphocytes was regulated by interleukin 15, which induced local chromatin modifications specific for the variable gamma-region gene segment and enhanced accessibility conducive to subsequent targeted gene rearrangement. This cytokine-directed tissue-specific TCR repertoire formation probably reflects distinct TCR repertoire selection criteria for gammadelta and alphabeta T cell lineages adopted for different antigen-recognition strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.