ArticleJournal of clinical microbiology2005
Molecular epidemiology of clinical Cryptococcus neoformans strains from India.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 92 citations in OpenAlex.
- Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin.PLoS pathogens · 2011Trial
- Early clinical and microbiological predictors of outcome in hospitalized patients with cryptococcal meningitis.BMC infectious diseases · 2022Article
- Epidemiology and Antifungal Susceptibility Patterns of Invasive Fungal Infections (IFIs) in India: A Prospective Observational Study.Journal of fungi (Basel, Switzerland) · 2021Article
- Multilocus Sequence Typing of Clinical Isolates of Cryptococcus from India.Mycopathologia · 2021Article
- Ecoepidemiology of Cryptococcus gattii in Developing Countries.Journal of fungi (Basel, Switzerland) · 2017Review
- Distribution and association between environmental and clinical isolates of Cryptococcus neoformans in Bogotá-Colombia, 2012-2015.Memorias do Instituto Oswaldo Cruz · 2016Article
- Cryptococcus neoformans var. grubii Infection in HIV-Seronegative Patients from Northeast India: Report of Two Cases with Review of Literature.Mycopathologia · 2016Review
- Article
- Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2015Review
- Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts.Fungal genetics and biology : FG & B · 2015Review
- Generation of stable mutants and targeted gene deletion strains in Cryptococcus neoformans through electroporation.Medical mycology · 2015Article
- Characterization of the virulence of Cryptococcus neoformans strains in an insect model.Virulence · 2015Article
- Abdominal Lymphonodular Cryptococcosis in an Immunocompetent Child.Case reports in pediatrics · 2015Article
- Aging: an emergent phenotypic trait that contributes to the virulence of Cryptococcus neoformans.Future microbiology · 2015Article
- Retrospective study of the epidemiology and clinical manifestations of Cryptococcus gattii infections in Colombia from 1997-2011.PLoS neglected tropical diseases · 2014Article
- Meningitis Due to Cryptococcus gattii in an Immunocompetent Patient.Journal of clinical and diagnostic research : JCDR · 2013Article
- Article
- Human immunodefeciency virus associated cryptococcal meningitis at a tertiary care centre: diagnostic tools and antifungal susceptibility testing.Journal of clinical and diagnostic research : JCDR · 2013Article
- Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence.G3 (Bethesda, Md.) · 2013Article
- Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Little is known about the molecular epidemiology of the human pathogenic fungus Cryptococcus neoformans in India, a country now in the midst of an epidemic of AIDS-related cryptococcosis. We studied 57 clinical isolates from several regions in India, of which 51 were C. neoformans var. grubii, 1 was C. neoformans var. neoformans, and 5 were C. neoformans var. gattii. This strain set included 18 additional sequential isolates from 14 patients. Strains were characterized phenotypically by measuring the polysaccharide capsule and by determining the MICs of standard antifungals. Molecular typing was performed by a PCR-based method using the minisatellite-specific core sequence (M13), by electrophoretic karyotyping, by restriction fragment length polymorphisms with the C. neoformans transposon 1 (TCN-1), and by URA5 DNA sequence analysis. Overall, Indian isolates were less heterogeneous than isolates from other regions and included a subset that clustered into one group based on URA5 DNA sequence analysis. In summary, our results demonstrate (i) differences in genetic diversity of C. neoformans isolates from India compared to isolates from other regions in the world; (ii) that DNA typing with the TCN-1 probe can adequately distinguish C. neoformans var. grubii strains; (iii) that TCN-1 sequences are absent in many C. neoformans var. gattii strains, supporting previous studies indicating that these strains have a limited geographical dispersal; and (iv) that human cryptococcal infection can be associated with microevolution of the infecting strain and by simultaneous coinfection with two distinct C. neoformans strains.
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Registered trials
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