ArticleJournal of clinical microbiology2005
Population structure and properties of Candida albicans, as determined by multilocus sequence typing.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed.
- Article
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- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Multilocus sequence typing of Candida albicans oral isolates reveals high genetic relatedness of mother-child dyads in early life.PloS one · 2024Article
- Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023Article
- Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease.PLoS biology · 2023Article
- A New Phenotype inmBio · 2023Article
- Molecular epidemiology ofFrontiers in veterinary science · 2023Article
- Molecular Phylogenetic Analysis of Candida krusei.Mycopathologia · 2022Article
- Article
- Multilocus Sequence Typing and Antifungal Susceptibility ofFrontiers in veterinary science · 2022Article
- Danish Whole-Genome-SequencedJournal of fungi (Basel, Switzerland) · 2021Article
- Differentiation ofCurrent medical mycology · 2021Article
- Molecular Diversity and Genetic Relatedness of Candida albicans Isolates from Birds in Hungary.Mycopathologia · 2021Article
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis.Iranian biomedical journal · 2020Article
- Article
- Genotyping Reveals High Clonal Diversity and Widespread Genotypes ofFrontiers in cellular and infection microbiology · 2020Article
- The Impact of Gene Dosage and Heterozygosity on The Diploid PathobiontJournal of fungi (Basel, Switzerland) · 2019Review
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
32 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
We submitted a panel of 416 isolates of Candida albicans from separate sources to multilocus sequence typing (MLST). The data generated determined a population structure in which four major clades of closely related isolates were delineated, together with eight minor clades comprising five or more isolates. By Fisher's exact test, a statistically significant association was found between particular clades and the anatomical source, geographical source, ABC genotype, decade of isolation, and homozygosity versus heterozygosity at the mating type-like locus (MTL) of the isolates in the clade. However, these associations may have been influenced by confounding variables, since in a univariate analysis of variance, only the clade associations with ABC type and anatomical source emerged as statistically significant, providing the first indication of possible differences between C. albicans strain type clades and their propensity to infect or colonize different anatomical locations. There were no significant differences between clades with respect to distributions of isolates resistant to fluconazole, itraconazole, or flucytosine. However, the majority of flucytosine-resistant isolates belonged to clade 1, and these isolates, but not flucytosine-resistant isolates in other clades, bore a unique mutation in the FUR1 gene that probably accounts for their resistance. A significantly higher proportion of isolates resistant to fluconazole, itraconazole, and flucytosine were homozygous at the MTL, suggesting that antifungal pressure may trigger a common mechanism that leads both to resistance and to MTL homozygosity. The utility of MLST for determining clade assignments of clinical isolates will form the basis for strain selection for future research into C. albicans virulence.
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