ArticleJournal of clinical microbiology2005
Molecular evolution of methicillin-resistant Staphylococcus aureus in the metropolitan area of Cologne, Germany, from 1984 to 1998.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Thermal shock susceptibility and regrowth of Pseudomonas aeruginosa biofilms.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2018Article
- Rapid Detection of Methicillin-Resistant Staphylococcus aureus Isolates by Turanose Fermentation Method.Jundishapur journal of microbiology · 2015Article
- Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Review
- Antimicrobial resistance and molecular epidemiology of Staphylococcus aureus from Ulaanbaatar, Mongolia.PeerJ · 2013Article
- Evaluation of quantitative antibiotic susceptibility testing by Vitek 2 as a routine method to predict strain relatedness of coagulase-negative staphylococci isolated from blood cultures.Journal of clinical microbiology · 2011Article
- Molecular characterization of methicillin-resistant Staphylococcus aureus isolates in Korea.Journal of clinical microbiology · 2011Article
- First detection of an invasive Staphylococcus aureus strain (D958) with reduced susceptibility to glycopeptides in Saudi Arabia.Journal of clinical microbiology · 2010Article
- Molecular characterization of resistance to Rifampicin in an emerging hospital-associated Methicillin-resistant Staphylococcus aureus clone ST228, Spain.BMC microbiology · 2010Article
- Imported methicillin-resistant Staphylococcus aureus, Sweden.Emerging infectious diseases · 2010Article
- Population structure of a hybrid clonal group of methicillin-resistant Staphylococcus aureus, ST239-MRSA-III.PloS one · 2010Article
- Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.Journal of bacteriology · 2009Article
- Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage.BMC genomics · 2008Article
- Countrywide molecular survey of methicillin-resistant Staphylococcus aureus strains in Poland.Journal of clinical microbiology · 2008Article
- Clonality of epidemic methicillin-resistant Staphylococcus aureus strains in Finland as defined by several molecular methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008Article
- Staphylococcal cassette chromosome mec in MRSA, Taiwan.Emerging infectious diseases · 2007Article
- Longitudinal study of the molecular epidemiology of methicillin-resistant Staphylococcus aureus at a university hospital.Journal of clinical microbiology · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the molecular evolution of methicillin-resistant Staphylococcus aureus (MRSA) in a large metropolitan area in Germany, 398 nonrepetitive MRSA isolates recovered from patients from various teaching and nonteaching hospitals in Cologne between 1984 and 1998 were characterized by pulsed-field gel electrophoresis (PFGE). On this basis, 95 representative isolates were selected and further investigated by multilocus sequence typing (MLST), spa typing, and staphylococcal cassette chromosome mec (SCCmec) typing. Overall, there were 9 MLST types and 16 spa types. The most prevalent sequence types (STs) were ST239 (38% of isolates), ST247 (29%), and ST228 (18%); the most prevalent spa types were 37 (32%) and 51 (29%). ST239 comprised five major PFGE types and various unique PFGE patterns, and ST5 comprised two PFGE types. While the same PFGE pattern was not observed among strains with different STs, spa type 37 was observed among strains representing two different STs (ST239 and ST241), and these belonged to the same clonal complex as single-locus variants. ST239 was the earliest predominant ST, with the highest prevalence from 1984 to 1988 (96%), followed by ST247 from 1989 to 1993 (83%) and ST228 from 1994 to 1998 (40%). Spa type 37 was the most prevalent from 1984 to 1988 (96%), spa type 51 was the most prevalent from 1989 to 1993 (83%), and spa types 1 and 458 were the most prevalent from 1994 to 1998 (26% and 14%, respectively). The prevalence of SCCmec type III decreased from 96% from 1984 to 1988 to 8% from 1989 to 1993, the prevalence of SCCmec type I increased from 4% from 1984 to 1988 to 97% from 1989 to 1993 and decreased to 62% from 1994 to 1998. While the genetic diversity of MRSA increased from 1984 to 1998, one prevalent ST usually accounted for most of the isolates in a given time period.
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