ArticleGenetics2006
Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Natural genetic variation in a dopamine receptor is associated with variation in female fertility inProceedings. Biological sciences · 2023Article
- The selection force weakens with age because ageing evolves and not vice versa.Nature communications · 2022Article
- Does the lack of heritability of human sex ratios require a rethink of sex ratio theory? No: a Comment on ZietschProceedings. Biological sciences · 2021Article
- Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.BMC biology · 2020Article
- Age influences the thermal suitability ofProceedings. Biological sciences · 2020Article
- Review
- Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype.Ecology and evolution · 2018Article
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
- Selection for narrow gate of emergence results in correlated sex-specific changes in life history of Drosophila melanogaster.Biology open · 2014Article
- Review
- Article
- Analyzing age-specific genetic effects on human extreme age survival in cohort-based longitudinal studies.European journal of human genetics : EJHG · 2013Article
- Detecting genetic variants for extreme aging using multiple data sources.European journal of human genetics : EJHG · 2013Article
- Age-specific variation in immune response in Drosophila melanogaster has a genetic basis.Genetics · 2012Article
- Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin.PLoS genetics · 2012Article
- New experiments for an undivided genetics.Genetics · 2011Article
- Statistical modelling of growth using a mixed model with orthogonal polynomials.Journal of applied genetics · 2011Article
- A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.Frontiers in genetics · 2011Article
- A conserved role for syndecan family members in the regulation of whole-body energy metabolism.PloS one · 2010Article
- Mutation and the evolution of ageing: from biometrics to system genetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Life-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic contribution to variation in fitness components, we know very little about the underlying genetic architecture of such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at 1 and 4 weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity on the third chromosome, but these QTL affected fecundity only at 1 week of age. There was more genetic variation for fecundity at 4 weeks of age than at 1 week of age and there was no genetic correlation between early and late-age fecundity. These results suggest that different loci contribute to the variation in fecundity as the organism ages. Our data provide support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life-span QTL, we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of senescence in these lines as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.