Evidence map›Paper›PMID 16272408›Full record

ArticleGenetics2006

Diverse mitotic and interphase functions of condensins in Drosophila.

Neville Cobbe, Ellada Savvidou, Margarete M S Heck

Abstract read
In one paragraph

Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
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  11. Article
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  13. Article
  14. SMC complexes link gene expression and genome architecture.Current opinion in genetics & development · 2014
    Review
  15. Condensins and 3D Organization of the Interphase Nucleus.Current genetic medicine reports · 2013
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Neville CobbeWellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.
Ellada Savvidou
Margarete M S Heck

Funding

Wellcome Trust
6 · The paper itself

Abstract

The condensin complex has been implicated in the higher-order organization of mitotic chromosomes in a host of model eukaryotes from yeasts to flies and vertebrates. Although chromosomes paradoxically appear to condense in condensin mutants, chromatids are not properly resolved, resulting in chromosome segregation defects during anaphase. We have examined the role of different condensin complex components in interphase chromatin function by examining the effects of various condensin mutations on position-effect variegation in Drosophila melanogaster. Surprisingly, most mutations affecting condensin proteins were often found to result in strong enhancement of variegation in contrast to what might be expected for proteins believed to compact the genome. This suggests either that the role of condensin proteins in interphase differs from their expected role in mitosis or that the way we envision condensin's activity needs to be modified to accommodate alternative possibilities.

Indexed as

Adenosine TriphosphatasesAmino Acid SequenceAnimalsApoptosisCell Cycle ProteinsDNA-Binding ProteinsDrosophila melanogasterEyeGene ExpressionHumansInterphaseLarvaMitosisMolecular Sequence DataMultiprotein ComplexesPigmentationAdenosine TriphosphatasesCell Cycle Proteinscondensin complexesDNA-Binding ProteinsMultiprotein Complexes

Identifiers

PMID16272408
PMCPMC1456240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.