ArticleWorld journal of gastroenterology2005
Effects of social isolation stress on immune response and survival time of mouse with liver cancer.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling.Science advances · 2026Article
- Small-area spatio-temporal analysis of cancer risk to support effective and equitable cancer prevention.PloS one · 2025Article
- Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions.International journal of molecular sciences · 2022Review
- A Cross-Sectional Exploration of Cytokine-Symptom Networks in Breast Cancer Survivors Using Network Analysis.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2021Article
- High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation.Brain and behavior · 2021Article
- Article
- Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.Annual review of physiology · 2020Review
- Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk.Endocrine-related cancer · 2016Article
- One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition.Acta neuropathologica · 2015Review
- Role of social factors on cell death, cerebral plasticity and recovery after stroke.Metabolic brain disease · 2015Review
- Article
- Psychosocial stress and liver disease status.World journal of gastroenterology · 2009Review
- Psychological stress-induced oxidative stress as a model of sub-healthy condition and the effect of TCM.Evidence-based complementary and alternative medicine : eCAM · 2007Article
- Social regulation of gene expression in human leukocytes.Genome biology · 2007Article
- Chinese Medicine Enhancing Response Rates to Immunosuppressant PD-L1 Inhibitor and Improving the Quality of Life of Hepatocellular Carcinoma-Bearing Mice.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of isolation stress on mouse with liver cancer and possible associated mechanisms.
methodsTransplantable murine hepatoma22 (H22) model was used to evaluate the effects of social isolation stress on murine liver cancer. Mice were immunized with sheep red blood cell (SRBC) and intraperitoneally inoculated with H22 cell, then divided into two groups, one reared individually as group (I) and the other reared in groups as group (G). Titer of antibody to SRBC and interleukin 2 (IL-2) in serum was monitored. The survival time of mouse with liver cancer was observed.
resultsThe titer of antibody to SRBC in group (G) was 1:24.5 and that in group (I) was 1:11.2. There was a significant difference between these two groups (t = 2.60, P = 0.02). A significant difference in IL-2 concentration was observed between group (G) (39.6 ng/L) and group (I) (47.1 ng/L, t = 2.14, P = 0.046). The survival time in group (G) (16.5 d) was markedly longer than that in group (I) (13.2 d, t = 3.46, P = 0.002).
conclusionOur study suggests that survival time of the mouse bearing H22 tumor is affected by the social isolation stress and the associated mechanism may be the immunological changes under the social isolation stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.