ArticleWorld journal of gastroenterology2005
Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Development and Validation of a Nomogram Predictive Model for Massive Ascites After Hepatectomy in Patients with Primary Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Article
- Diagnostic value of serum inflammatory markers in predicting early refractoriness of transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer Stage 0, A, and B hepatocellular carcinoma.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Tyrosine phosphorylation of YAP-1 in biliary epithelial cells mediates posthepatectomy liver regeneration and is affected by serotonin.Journal of cellular biochemistry · 2023Article
- Estimating the Individual Treatment Effect on Survival Time Based on Prior Knowledge and Counterfactual Prediction.Entropy (Basel, Switzerland) · 2022Article
- Consequences of Perioperative Serotonin Reuptake Inhibitor Treatment During Hepatic Surgery.Hepatology (Baltimore, Md.) · 2021Article
- Issues to be considered to address the future liver remnant prior to major hepatectomy.Surgery today · 2021Review
- Prediction of Post-hepatectomy Liver Failure in Patients With Hepatocellular Carcinoma Based on Radiomics Using Gd-EOB-DTPA-Enhanced MRI: The Liver Failure Model.Frontiers in oncology · 2021Article
- Platelet and liver regeneration after liver surgery.Surgery today · 2020Review
- High Inflammatory Factor Grading Predicts Poor Disease-Free Survival in AJCC Stage I-II Hepatocellular Carcinoma Patients After R0 Resection.Cancer management and research · 2019Article
- Association between the expression levels of IL-6 and IL-6R in the hepatocellular carcinoma microenvironment and postoperative recurrence.Oncology letters · 2018Article
- Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma.Annals of hepato-biliary-pancreatic surgery · 2018Article
- Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy.Canadian journal of gastroenterology & hepatology · 2018Article
- How small is TOO small? New liver constraint is needed- Proton therapy of hepatocellular carcinoma patients with small normal liver.PloS one · 2018Article
- Prognostic Impact of Indocyanine Green Plasma Disappearance Rate in Hepatocellular Carcinoma Patients after Radiofrequency Ablation: A Prognostic Nomogram Study.Internal medicine (Tokyo, Japan) · 2017Article
- Impaired liver function attenuates liver regeneration and hypertrophy after portal vein embolization.World journal of hepatology · 2016Article
- Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin.Stem cells international · 2016Review
- Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy.World journal of gastroenterology · 2014Observational
- Importance of low preoperative platelet count in selecting patients for resection of hepatocellular carcinoma: a multi-institutional analysis.Journal of the American College of Surgeons · 2011Article
- A review of factors predicting perioperative death and early outcome in hepatopancreaticobiliary cancer surgery.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
aimTo assess the validity of our selection criteria for hepatectomy procedures based on indocyanine green disappearance rate (K(ICG)), and to unveil the factors affecting posthepatectomy mortality in patients with hepatocellular carcinoma (HCC).
methodsA retrospective analysis of 198 consecutive patients with HCC who underwent partial hepatectomies in the past 14 years was conducted. The selection criteria for hepatectomy procedures during the study period were K(ICG)>or=0.12 for hemihepatectomy, K(ICG)>or=0.10 for bisegmentectomy, K(ICG)>or=0.08 for monosegmentectomy, and K(ICG)>or=0.06 for nonanatomic hepatectomy. The hepatectomies were categorized into three types: major hepatectomy (hemihepatectomy or a more extensive procedure), bisegmentectomy, and limited hepatectomy. Univariate (Fisher's exact test) and multivariate (the logistic regression model) analyses were used.
resultsPostoperative mortality was 5% after major hepatectomy, 3% after bisegmentectomy, and 3% after limited hepatectomy. The three percentages were comparable (P = 0.876). The platelet count of <or=10X10(4)/microL was the strongest independent factor for postoperative mortality on univariate (P = 0.001) and multivariate (risk ratio, 12.5; P = 0.029) analyses. No patient with a platelet count of >7.3X10(4)/microL died of postoperative morbidity, whereas 25% (6/24 patients) of patients with a platelet count of <or=7.3X10(4)/microL died (P<0.001).
conclusionThe selection criteria for hepatectomy procedures based on K(ICG) are generally considered valid, because of the acceptable morbidity and mortality with these criteria. The preoperative platelet count independently affects morbidity and mortality after hepatectomy, suggesting that a combination of K(ICG) and platelet count would further reduce postoperative mortality.
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