ArticlePediatric nephrology (Berlin, Germany)2006
Factors affecting histological regression of crescentic Henoch-Schönlein nephritis in children.
Article in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 34 citations in OpenAlex.
- Association of kidney biopsy findings with short- and medium-term outcomes in children with moderate-to-severe IgA vasculitis nephritis.European journal of pediatrics · 2021Article
- A clinicopathological comparison between IgA nephropathy and Henoch-Schönlein purpura nephritis in children: use of the Oxford classification.Clinical and experimental nephrology · 2019Article
- Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.Pediatric nephrology (Berlin, Germany) · 2019Article
- Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.Italian journal of pediatrics · 2018Article
- Presentation of pediatric Henoch-Schönlein purpura nephritis changes with age and renal histology depends on biopsy timing.Pediatric nephrology (Berlin, Germany) · 2018Article
- The significance of tubulointerstitial lesions in childhood Henoch-Schönlein nephritis.Pediatric nephrology (Berlin, Germany) · 2016Article
- Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomes.Pediatric nephrology (Berlin, Germany) · 2011Article
- Predictors of outcome in Henoch-Schönlein nephritis.Pediatric nephrology (Berlin, Germany) · 2010Article
- Treatment-based literature of Henoch-Schönlein purpura nephritis in childhood.Pediatric nephrology (Berlin, Germany) · 2009Review
- Treating severe Henoch-Schönlein and IgA nephritis with plasmapheresis alone.Pediatric nephrology (Berlin, Germany) · 2007Article
- Henoch-Schonlein purpura: polymorphisms in thrombophilia genes.Pediatric nephrology (Berlin, Germany) · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To identify the factors affecting histological regression of crescentic Henoch-Schönlein nephritis (HSN), we retrospectively analyzed serially biopsied 20 children with crescentic HSN treated with immunosuppressants. They were classified into two groups according to the histological changes between the first and second biopsy: group I (n=10) with histological regression and group II (n=10) with no change or histological progression. Of the 20 patients, 19 showed a favorable outcome at the end of follow-up. Initial laboratory and histological findings did not differ between the two groups. Histological regression was associated with a younger age at onset (P=0.003), early treatment with immunosuppressants (P=0.044) and absent or decreased fibrinogen deposits at the second biopsy (P<0.0001) in a univariate analysis. Mesangial IgA and fibrinogen depositions at the second biopsy were reduced significantly in group I (P<0.05). In the multivariate analysis, a younger age was an independent determinant of histological regression (OR 1.44; 95% CI 1.03-2.02). The intensity of fibrinogen deposits at the second biopsy correlated positively with the age at onset (r=0.503, P=0.024), and the chronicity index at the second biopsy correlated positively with the time that immunosuppressive therapy was started (r=0.619, P=0.004).
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