ArticleHistochemistry and cell biology2006
Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats.Clinical oral investigations · 2024Article
- Expression of phosphate and calcium transporters and their regulators in parotid glands of mice.Pflugers Archiv : European journal of physiology · 2023Article
- TRPV6 as A Target for Cancer Therapy.Journal of Cancer · 2020Review
- Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice.Journal of cellular physiology · 2018Article
- Homer2 protein regulates plasma membrane Ca²⁺-ATPase-mediated Ca²⁺ signaling in mouse parotid gland acinar cells.The Journal of biological chemistry · 2014Article
- Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1.The Journal of biological chemistry · 2013Article
- Extracellular Ca(2+) sensing in salivary ductal cells.The Journal of biological chemistry · 2012Article
- Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai.Journal of Zhejiang University. Science. B · 2008Review
- Transcellular calcium transport in mammary epithelial cells.Journal of mammary gland biology and neoplasia · 2007Article
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- Article
- Identification and subcellular localization of paracellin-1 (claudin-16) in human salivary glands.Histochemistry and cell biology · 2007Article
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary calcium plays a vital role in bio-mineralization of dental enamel and exposed dentin. In order to elucidate the yet unknown cellular and molecular mechanisms of calcium secretion in human salivary glands the presence of various relevant plasma membrane transport systems for calcium were investigated. Using an RT-PCR approach, expression of the epithelial calcium channel (CaT-Like), the calcium binding protein (calbindin-2), the endoplasmic reticulum pumps (SERCA-2 and -3), and the plasma membrane calcium ATPases (PMCA-1, -2, and -4), were found in parotid and submandibular glands. Immunohistochemistry revealed that CaT-Like is located in the basolateral plasma membrane of acinar cells; while calbindin-2, SERCA-2 and SERCA-3 were found inside the acinar cells; and PMCA-2 was found in the apical membrane and in the secretory canaliculi between the cells. Based on these findings, we propose the following model of calcium secretion in human salivary glands: (1) calcium enters the acinar cell at the basolateral side via calcium channel CaT-Like (calcium influx); (2) intracellular calcium is taken up into the endoplasmic reticulum by SERCA-2 and possibly SERCA3 or bound to calbindin-2 (intracellular calcium pool); and (3) calcium is secreted by PMCAs at the apical plasma membrane (calcium efflux).
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