ArticleThe Journal of physiology2006
The influence of mouse Ped gene expression on postnatal development.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome.Frontiers in immunology · 2021Article
- The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.Human reproduction (Oxford, England) · 2020Article
- New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy.Frontiers in immunology · 2018Review
- Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter.Journal of anatomy · 2009Review
- The role of tapasin in MHC class I protein trafficking in embryos and T cells.Journal of reproductive immunology · 2008Article
- Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.The Journal of physiology · 2008Article
- Preimplantation embryo development (Ped) gene copy number varies from 0 to 85 in a population of wild mice identified as Mus musculus domesticus.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels.Journal of assisted reproduction and genetics · 2006Article
- Dynamic expression of Qa-2 during acute graft rejection.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P < 0.05) and had elevated systolic blood pressure at 21 weeks of age when compared with B6.K2 mice (P = 0.006). B6.K1 mice also demonstrated elevated serum angiotensin-converting enzyme (ACE) activity, a known regulator of blood pressure (P = 0.037). Altered organ:body weight ratios were also observed, with the B6.K1 females having a higher ratio for lungs than B6. K2 females (P = 0.014). These data provide evidence of an association between the rate of preimplantation embryo development, postnatal growth and later cardiovascular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.