ArticleClinical rheumatology2006
Adrenal axis functions in patients with familial Mediterranean fever.
Article in Clinical rheumatology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Tertiary adrenal insufficiency in a patient with familial Mediterranean fever: Association or coincidence?Archives of rheumatology · 2024Article
- Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever.BMJ case reports · 2013Article
- Is there a real adrenal axis dysfunction in patients with amyloidosis associated with familial Mediterranean fever?Rheumatology international · 2012Article
- Acute adrenal crisis mimicking familial Mediterranean fever attack in a renal transplant FMF patient with amyloid goiter.Rheumatology international · 2010Article
- Is there a hypothalamic-pituitary-adrenal axis dysfunction in patients with familial Mediterranean fever?Clinical rheumatology · 2006Article
Corrections and comments
- Erratum issuedTansu, Sav [corrected to Sav, Tansu]; Omer, Ozbakir [corrected to Ozbakir, Omer]; Fahrettin, Kelestimur [corrected to Kelestimur, Fahrettin]; Sebnem, Gursoy [corrected to Gursoy, Sebnem]; Mevlut, Baskol [corrected to Baskol, Mevlut]; Mustafa, Kula [correct
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFamilial Mediterranean fever (FMF) is a hereditary disease characterized by recurrent attacks of fever with peritonitis, arthritis, pleuritis or erysipelas-like rash. It is unclear what effects of FMF itself on endocrine system and hormones are. None of the FMF patients without amyloidosis have been reported to have any endocrine disorders, except those who developed colchicine-induced diabetes insipidus. There is a large body of evidence to show that cytokines (IL-1, IL-6 and TNF-alpha) activate the hypothalamic-pituitary-adrenal (HPA) axis. We have designated this study to investigate the HPA axis in FMF patients without amyloidosis.
methodsTwenty-one patients with FMF were included. ACTH stimulation test was performed on the healthy subjects and during attack period in the patients. In the patient group, same test was repeated during remission period.
resultsPeak cortisol levels were significantly higher in the attack period than those in the remission period of patients (p<0.05).
conclusionThe cytokines play a role on the activation of the HPA axis; we thought the axis would be affected in this disease. The response of cortisol to 250 mug ACTH was significant in attack period when compared with remission period. This result reveals that HPA axis is more activated in an FMF attack. Previous studies suggest that the adrenal hormones increase in acute inflammatory events, and eventually, the changes on these hormones are related to TNF and IL-6 levels. During the FMF attack, HPA axis may be stimulated by cytokines. It seems that HPA axis is regulated normally in FMF patients.
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