ArticleJournal of bacteriology2005
Bacillus subtilis cysteine synthetase is a global regulator of the expression of genes involved in sulfur assimilation.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- L-cysteine inhibited the growth ofApplied and environmental microbiology · 2026Article
- Integrative phylogenomic and pangenome landscape of Bacillus: insights from 10,000 genomes into taxonomy, functional potential, and biotechnological applications.World journal of microbiology & biotechnology · 2026Article
- Priestia megaterium reduces hydrogen sulfide level in swine manure potentially through an assimilatory mechanism and microbiota modulation.Applied microbiology and biotechnology · 2026Article
- Complete genome sequence ofJournal of animal science and technology · 2025Article
- Effects of l-Serine on Macrolide Resistance in Streptococcus suis.Microbiology spectrum · 2022Article
- A CysB regulator positively regulates cysteine synthesis, expression of type III secretion system genes, and pathogenicity in Ralstonia solanacearum.Molecular plant pathology · 2022Article
- NrnA Is a Linear Dinucleotide Phosphodiesterase with Limited Function in Cyclic Dinucleotide Metabolism in Listeria monocytogenes.Journal of bacteriology · 2022Article
- Whole-Genome and Transcriptome Sequencing-Based Characterization ofFrontiers in microbiology · 2022Article
- Comparative Proteomic Analysis Reveals Antibacterial Mechanism ofInfection and drug resistance · 2022Article
- Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics.ACS infectious diseases · 2017Article
- Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein.Biochimica et biophysica acta · 2015Review
- TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans.FEMS microbiology letters · 2012Article
- Coproporphyrin excretion and low thiol levels caused by point mutation in the Rhodobacter sphaeroides S-adenosylmethionine synthetase gene.Journal of bacteriology · 2010Article
- Article
- Evolutionarily conserved optimization of amino acid biosynthesis.Journal of molecular evolution · 2007Article
- Conversion of methionine to cysteine in Bacillus subtilis and its regulation.Journal of bacteriology · 2007Article
- Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria.Journal of bacteriology · 2006Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of L-cysteine, the major mechanism by which sulfur is incorporated into organic compounds in microorganisms, occupies a significant fraction of bacterial metabolism. In Bacillus subtilis the cysH operon, encoding several proteins involved in cysteine biosynthesis, is induced by sulfur starvation and tightly repressed by cysteine. We show that a null mutation in the cysK gene encoding an O-acetylserine-(thiol)lyase, the enzyme that catalyzes the final step in cysteine biosynthesis, results in constitutive expression of the cysH operon. Using DNA microarrays we found that, in addition to cysH, almost all of the genes required for sulfate assimilation are constitutively expressed in cysK mutants. These results indicate that CysK, besides its enzymatic role in cysteine biosynthesis, is a global negative regulator of genes involved in sulfur metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.