ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Little Known Facts, Controversies and Misconceptions About Cranial Motor Nuclei (and a New Classification for All Motoneurons, Cranial, and Spinal).The Journal of comparative neurology · 2026Review
- A detailed review of the spinal accessory nerve and its anatomical variations with cadaveric illustration.Anatomical science international · 2024Review
- A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types.Science advances · 2024Article
- Transcriptional Control of Axon Guidance at Midline Structures.Frontiers in cell and developmental biology · 2022Review
- Gene set enrichment analysis and protein-protein interaction network analysis after sciatic nerve injury.Annals of translational medicine · 2020Article
- Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.Nature reviews. Neuroscience · 2019Review
- Restoring Motor Neurons in Spinal Cord Injury With Induced Pluripotent Stem Cells.Frontiers in cellular neuroscience · 2019Review
- Proteomic profile of embryonic stem cells with low survival motor neuron protein is consistent with developmental dysfunction.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse.Frontiers in molecular neuroscience · 2016Article
- Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.Genes & development · 2015Article
- Phenotypic analysis of mice completely lacking netrin 1.Development (Cambridge, England) · 2015Article
- Netrin-1 directs dendritic growth and connectivity of vertebrate central neurons in vivo.Neural development · 2015Article
- Evolutionary and developmental understanding of the spinal accessory nerve.Zoological letters · 2015Review
- Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.PloS one · 2015Article
- Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain.PloS one · 2015Article
- Transcription factors and effectors that regulate neuronal morphology.Development (Cambridge, England) · 2014Review
- The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.BMC genomics · 2014Article
- Transcriptional regulation of guidance at the midline and in motor circuits.Cellular and molecular life sciences : CMLS · 2014Review
- Motor neurons and the generation of spinal motor neuron diversity.Frontiers in cellular neuroscience · 2014Review
- FUS-regulated RNA metabolism and DNA damage repair: Implications for amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis.Rare diseases (Austin, Tex.) · 2014Article
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Authors and funding
10 authors.
Funding
Abstract
Within the developing vertebrate spinal cord, motor neuron subtypes are distinguished by the settling positions of their cell bodies, patterns of gene expression, and the paths their axons follow to exit the CNS. The inclusive set of cues required to guide a given motor axon subtype from cell body to target has yet to be identified, in any species. This is attributable, in part, to the unavailability of markers that demarcate the complete trajectory followed by a specific class of spinal motor axons. Most spinal motor neurons extend axons out of the CNS through ventral exit points. In contrast, spinal accessory motor neurons (SACMNs) project dorsally directed axons through lateral exit points (LEPs), and these axons assemble into the spinal accessory nerve (SAN). Here we show that an antibody against BEN/ALCAM/SC1/DM-GRASP/MuSC selectively labels mouse SACMNs and can be used to trace the pathfinding of SACMN axons. We use this marker, together with a battery of transcription factor-deficient or guidance cue/receptor-deficient mice to identify molecules required for distinct stages of SACMN development. Specifically, we find that Gli2 is required for the initial extension of axons from SACMN cell bodies, and that netrin-1 and its receptor Dcc are required for the proper dorsal migration of these cells and the dorsally directed extension of SACMN axons toward the LEPs. Furthermore, in the absence of the transcription factor Nkx2.9, SACMN axons fail to exit the CNS. Together, these findings suggest molecular mechanisms that are likely to regulate key steps in SACMN development.
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