ArticleProceedings of the National Academy of Sciences of the United States of America2005
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed.
- The expanded inhibitor of apoptosis gene family in oysters possesses novel domain architectures and may play diverse roles in apoptosis following immune challenge.BMC genomics · 2022Article
- RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.International journal of molecular sciences · 2021Article
- E3 Ubiquitin Ligase SPL2 Is a Lanthanide-Binding Protein.International journal of molecular sciences · 2021Article
- Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.Investigational new drugs · 2020Article
- Article
- Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.The Journal of biological chemistry · 2019Article
- Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.Leukemia · 2018Article
- Immunology and Genetic ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity.Scientific reports · 2017Article
- The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions.Cellular & molecular immunology · 2016Review
- Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP.Journal of virology · 2016Article
- Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.EMBO molecular medicine · 2015Article
- Absence of RIPK3 predicts necroptosis resistance in malignant melanoma.Cell death & disease · 2015Article
- Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.PLoS genetics · 2015Article
- HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization.Oncotarget · 2014Article
- Small-molecule SMAC mimetics as new cancer therapeutics.Pharmacology & therapeutics · 2014Review
- The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin.Cell death & disease · 2014Article
- Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Wilms' tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma.Journal of gastroenterology · 2013Article
- Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitor of apoptosis (IAP) proteins, which bind to caspases via their baculoviral IAP repeat domains, also bear RING domains that enable them to promote ubiquitylation of themselves and other interacting proteins. Here we show that the RING domain of cIAP1 allows it to bind directly to the RING of X-linked IAP, causing its ubiquitylation and degradation by the proteasome, thus revealing a mechanism by which IAPs can regulate their abundance. Expression of a construct containing the RING of cellular IAP1 was able to deplete melanoma cells of endogenous X-linked IAP, promoted apoptosis, and also markedly reduced their clonogenicity when treated with cisplatin. Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.