ReviewDevelopment and psychopathology2005
A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children.
Review in Development and psychopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 81 citations in OpenAlex.
- Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice.Molecular psychiatry · 2026Article
- Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis.Journal of neurodevelopmental disorders · 2023Review
- The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders.Advances in neurobiology · 2023Article
- Synaptic Plasticity Dysfunctions in the Pathophysiology of 22q11 Deletion Syndrome: Is There a Role for Astrocytes?International journal of molecular sciences · 2022Review
- Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis-proneness symptoms in youth with chromosome 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2020Article
- Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome.Translational psychiatry · 2020Article
- Characteristics and Outcomes of Heart Transplantation in DiGeorge Syndrome.Pediatric cardiology · 2019Article
- Attentional functioning in individuals with 22q11 deletion syndrome: insight from ERPs.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Autism: a transdiagnostic, dimensional, construct of reasoning?The European journal of neuroscience · 2018Review
- Baseline connectome modular abnormalities in the childhood phase of a longitudinal study on individuals with chromosome 22q11.2 deletion syndrome.Human brain mapping · 2018Article
- The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety.Journal of psychiatry & neuroscience : JPN · 2016Article
- Disrupted fornix integrity in children with chromosome 22q11.2 deletion syndrome.Psychiatry research · 2015Article
- Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory.American journal on intellectual and developmental disabilities · 2014Article
- The development of cognitive control in children with chromosome 22q11.2 deletion syndrome.Frontiers in psychology · 2014Article
- Association of the family environment with behavioural and cognitive outcomes in children with chromosome 22q11.2 deletion syndrome.Journal of intellectual disability research : JIDR · 2014Article
- Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome.Neuropharmacology · 2013Review
- A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome.Frontiers in psychiatry · 2013Article
- A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2012Article
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
We present a multilevel approach to developing potential explanations of cognitive impairments and psychopathologies common to individuals with chromosome 22q11.2 deletion syndrome. Results presented support our hypothesis of posterior parietal dysfunction as a central determinant of characteristic visuospatial and numerical cognitive impairments. Converging data suggest that brain development anomalies, primarily tissue reductions in the posterior brain and changes to the corpus callosum, may affect parietal connectivity. Further findings indicate that dysfunction in "frontal" attention systems may explain some executive cognition impairments observed in affected children, and that there may be links between these domains of cognitive function and some of the serious psychiatric conditions, such as attention-deficit/hyperactivity disorder, autism, and schizophrenia, that have elevated incidence rates in the syndrome. Linking the neural structure and the cognitive processing levels in this way enabled us to develop an elaborate structure/function mapping hypothesis for the impairments that are observed. We show also, that in the case of the catechol-O-methyltransferase gene, a fairly direct relationship between gene expression, cognitive function, and psychopathology exists in the affected population. Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.