ReviewDialogues in clinical neuroscience2005
Genetic bases for endophenotypes in psychiatric disorders.
Review in Dialogues in clinical neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.Schizophrenia bulletin · 2015Pooled it
- Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia.Schizophrenia bulletin · 2013Pooled it
- Differences in executive function among patients with schizophrenia, their unaffected first-degree relatives and healthy participants.The international journal of neuropsychopharmacology · 2020Article
- Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.International journal of molecular sciences · 2018Review
- A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient.Frontiers in psychiatry · 2017Review
- Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.NeuroImage. Clinical · 2017Article
- Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit.Borderline personality disorder and emotion dysregulation · 2014Review
- Autism and the broad autism phenotype: familial patterns and intergenerational transmission.Journal of neurodevelopmental disorders · 2013Article
- Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families.Autism research : official journal of the International Society for Autism Research · 2012Article
- The broader autism phenotype and its implications on the etiology and treatment of autism spectrum disorders.Autism research and treatment · 2011Article
- Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: data from the COGS study.Psychophysiology · 2010Article
- Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.Psychiatry research · 2010Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
- Consider the context: blocked versus interleaved presentation of antisaccade trials.Psychophysiology · 2009Article
- Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives.Biological psychiatry · 2008Article
- Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?Schizophrenia bulletin · 2008Review
- Which perspectives can endophenotypes and biological markers offer in the early recognition of schizophrenia?Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- Mapping cortical thickness in children with 22q11.2 deletions.Cerebral cortex (New York, N.Y. : 1991) · 2007Article
- Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study.Behavioral and brain functions : BBF · 2007Article
- Schizophrenia proteomics: biomarkers on the path to laboratory medicine?Diagnostic pathology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reviews the concept of an endophenotype, with particular reference to heritability as well as diagnostic specificity. An endophenotype need not be heritable, for example, the possible influence of in utero viral infections for schizophrenia. However, heritability is a useful characteristic for a potential endophenotype, as it can be studied in relation to a plausible candidate gene. It should be noted that the traditional methods of demonstrating heritability, eg, twin studies, can be supplemented with DNA sequence studies, suggesting heritability. Endophenotypes need not be specific to a given nosological class of psychiatric disorders, as these classes do not reflect biological categories. Evidence for two useful schizophrenia endophenotypes, the P50 abnormalities and cognitive deficits, is summarized.
Indexed as
Identifiers
16262206PMC3181728W2137966916What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.