ArticleMammalian genome : official journal of the International Mammalian Genome Society2005
Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse.Frontiers in immunology · 2021Article
- Does size matter in platelet production?Blood · 2012Review
- QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Genetic analysis of hematological parameters in incipient lines of the collaborative cross.G3 (Bethesda, Md.) · 2012Article
- The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Journal of thrombosis and haemostasis : JTH · 2011Review
- Detection of quantitative trait loci affecting haematological traits in swine via genome scanning.BMC genetics · 2010Article
- Homeostatic regulation of blood neutrophil counts.Journal of immunology (Baltimore, Md. : 1950) · 2008Review
- Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc x Erhualian F(2) resource population.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.The Journal of clinical investigation · 2008Article
- Quantitative trait loci for peripheral blood cell counts: a study in baboons.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Quantitative trait loci for baseline erythroid traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A substantial genetic contribution to baseline peripheral blood counts has been established. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline white blood cell (WBC) count, platelet (Plt) count, and mean platelet volume (MPV) in F(2) intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice. We identified six significant WBC QTL: Wbcq1 (peak LOD score at 38 cM, Chr 1), Wbcq2 (42 cM, Chr 3), Wbcq3 (0 cM, Chr 15), Wbcq4 (58 cM, Chr 1), Wbcq5 (82 cM, Chr 1), and Wbcq6 (8 cM, Chr 14). Three significant Plt QTL were identified: Pltq1 (24 cM, Chr 2), Pltq2 (36 cM, Chr 7), and Pltq3 (10 cM, Chr 12). Two significant MPV QTL were identified, Mpvq1 (62 cM, Chr 15) and Mpvq2 (44 cM, Chr 8). In total, the WBC QTL accounted for up to 31% of the total variance in baseline WBC count, while the Plt and MPV QTL accounted for up to 30% and 49% of the total variance, respectively. These analyses underscore the genetic complexity underlying these traits in normal populations and provide the basis for future studies to identify novel genes involved in the regulation of mammalian hematopoiesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.