Evidence map›Paper›PMID 16261174›Full record

ReviewNature reviews. Immunology2005

Reconstructing immune phylogeny: new perspectives.

Gary W Litman, John P Cannon, Larry J Dishaw

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed.

  1. Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026
    Article
  2. Highlights on the Contribution of Gut Microbiota to Immune-Mediated Diseases in Childhood.Mediterranean journal of hematology and infectious diseases · 2026
    Review
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  10. Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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  19. Review
  20. Transcriptome Analysis Indicates Immune Responses againstAnimals : an open access journal from MDPI · 2022
    Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gary W LitmanDepartment of Pediatrics, University of South Florida College of Medicine, All Children's Hospital Children's Research Institute, 830 First Street South, Saint Petersburg, Florida 33701, USA. litmang@allkids.org
John P Cannon
Larry J Dishaw

Funding

EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESR01AI023338 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LITMAN, GARY WILLIAM · 1985 to 2014
$3.6M
NIAID NIH HHS R01 AI023338
6 · The paper itself

Abstract

Numerous studies of the mammalian immune system have begun to uncover profound interrelationships, as well as fundamental differences, between the adaptive and innate systems of immune recognition. Coincident with these investigations, the increasing experimental accessibility of non-mammalian jawed vertebrates, jawless vertebrates, protochordates and invertebrates has provided intriguing new information regarding the likely patterns of emergence of immune-related molecules during metazoan phylogeny, as well as the evolution of alternative mechanisms for receptor diversification. Such findings blur traditional distinctions between adaptive and innate immunity and emphasize that, throughout evolution, the immune system has used a remarkably extensive variety of solutions to meet fundamentally similar requirements for host protection.

Indexed as

Evolution, MolecularPhylogenyAnimalsGene Rearrangement, B-LymphocyteGene Rearrangement, T-LymphocyteGenes, ImmunoglobulinGenes, RAG-1Immunity, InnateInvertebratesReceptors, ImmunologicVertebratesReceptors, Immunologic

Identifiers

PMID16261174
PMCPMC3683834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.