ArticleOncogene2006
HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line.Bioengineered · 2024Article
- Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma.Journal of Cancer · 2018Article
- Identification of commonly altered genes between in major depressive disorder and a mouse model of depression.Scientific reports · 2017Article
- Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.PloS one · 2014Article
- Article
- Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.The Journal of clinical investigation · 2013Article
- Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.Molecular cancer · 2012Article
- Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Oncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines.World journal of gastroenterology · 2010Article
- Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection.Cancer science · 2010Article
- CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.The Journal of clinical investigation · 2010Article
- Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma.BMC cancer · 2007Article
- Nm23/NDP kinases in hepatocellular carcinoma.Journal of bioenergetics and biomembranes · 2006Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence tags (ESTs) from chromosome 8p and used to compare the difference of expression profiling between the MHCC97-H and MHCC97-L cell lines with different metastatic potentials and similar genetic backgrounds. In all, 10 ESTs were significantly downregulated in MHCC97-H cell line with higher metastatic potential. One full-length gene, HTPAP (phosphatidic acid phosphatase type 2 domain containing 1B), was identified at chromosome 8p12. Sequencing and bioinformatic analyses revealed that HTPAP has 826 bp and encodes a putative protein of 175 amino acids with a transmembrane segment at the NH2 terminus, two protein kinase C phosphorylation site and one tyrosine kinase phosphorylation site. Its expression level in metastatic tumor tissues was much lower than that of primary HCC tissues. Both in vitro and in vivo assays suggested that HTPAP could suppress the invasion and metastasis of HCC. These suggested that HTPAP is a novel metastatic suppressor gene for HCC. The mechanism of the effect of HTPAP on HCC metastasis is not clear yet and deserves further investigation.
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