ArticleProceedings of the National Academy of Sciences of the United States of America2005
Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 117 citations in OpenAlex.
- Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis.Journal of endocrinological investigation · 2019Trial
- Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods.BMC genomics · 2026Article
- Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases.PLoS computational biology · 2026Article
- Selected Trace Elements and Their Impact on Redox Homeostasis in Eye Health.Biomolecules · 2024Review
- Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio).Research square · 2024Article
- Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase.Genome biology and evolution · 2024Article
- The interplay of oxidative stress and immune dysfunction in Hashimoto's thyroiditis and polycystic ovary syndrome: a comprehensive review.Frontiers in immunology · 2023Review
- Intracellular mono-ADP-ribosyltransferases at the host-virus interphase.Cellular and molecular life sciences : CMLS · 2022Review
- The algal selenoproteomes.BMC genomics · 2020Article
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Bioinformatics of Metalloproteins and Metalloproteomes.Molecules (Basel, Switzerland) · 2020Review
- Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases.PLoS pathogens · 2018Article
- An overview of the ongoing insights in selenium research and its role in fish nutrition and fish health.Fish physiology and biochemistry · 2017Review
- The cuticular nature of corneal lenses in Drosophila melanogaster.Development genes and evolution · 2017Article
- Selenoprotein Gene Nomenclature.The Journal of biological chemistry · 2016Article
- Knockdown of 15-kDa selenoprotein (Sep15) increases hLE cells' susceptibility to tunicamycin-induced apoptosis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- Effects of acclimation salinity on the expression of selenoproteins in the tilapia, Oreochromis mossambicus.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2014Article
- SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.Nucleic acids research · 2014Article
- Expression and purification of the membrane enzyme selenoprotein K.Protein expression and purification · 2012Article
- Evolution of selenoproteins in the metazoan.BMC genomics · 2012Article
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11 authors at 4 institutions in 4 countries.
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Abstract
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has precluded the automatic annotation of selenoproteins. Recent advances in the computational identification of selenoprotein genes have provided a first glimpse of the size, functions, and phylogenetic diversity of eukaryotic selenoproteomes. Here, we describe the identification of a selenoprotein family named SelJ. In contrast to known selenoproteins, SelJ appears to be restricted to actinopterygian fishes and sea urchin, with Cys homologues only found in cnidarians. SelJ shows significant similarity to the jellyfish J1-crystallins and with them constitutes a distinct subfamily within the large family of ADP-ribosylation enzymes. Consistent with its potential role as a structural crystallin, SelJ has preferential and homogeneous expression in the eye lens in early stages of zebrafish development. A structural role for SelJ would be in contrast to the majority of known selenoenzymes. The unusually highly restricted phylogenetic distribution of SelJ, its specialization, and the comparative analysis of eukaryotic selenoproteomes reveal the diversity and functional plasticity of selenoproteins and point to a mosaic evolution of the use of Sec in proteins.
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