ArticleMolecular and cellular biology2005
Caveolin-1 is not essential for biosynthetic apical membrane transport.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia.Scientific reports · 2024Article
- Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.Molecular oncology · 2022Article
- Molecular Characterization of Hemorrhagic Enteritis Virus (HEV) Obtained from Clinical Samples in Western Canada 2017-2018.Viruses · 2020Article
- Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney.American journal of physiology. Renal physiology · 2014Article
- Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells.Journal of virology · 2013Article
- Epstein-Barr virus transcytosis through polarized oral epithelial cells.Journal of virology · 2013Article
- Caveolae as plasma membrane sensors, protectors and organizers.Nature reviews. Molecular cell biology · 2013Review
- Two distinct integrin-mediated mechanisms contribute to apical lumen formation in epithelial cells.PloS one · 2011Article
- Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner.PLoS pathogens · 2010Article
- Occludin is required for cytokine-induced regulation of tight junction barriers.Journal of cell science · 2010Article
- Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin.Journal of virology · 2010Article
- Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network.The Journal of cell biology · 2009Article
- The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit.Molecular biology of the cell · 2008Article
- Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes.Molecular biology of the cell · 2008Article
- The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolin-1 has been implicated in apical transport of glycosylphosphatidylinositol (GPI)-anchored proteins and influenza virus hemagglutinin (HA). Here we have studied the role of caveolin-1 in apical membrane transport by generating caveolin-1-deficient Madin-Darby canine kidney (MDCK) cells using retrovirus-mediated RNA interference. The caveolin-1 knockdown (cav1-KD) MDCK cells were devoid of caveolae. In addition, caveolin-2 was retained in the Golgi apparatus in cav1-KD MDCK cells. However, we found no significant alterations in the apical transport kinetics of GPI-anchored proteins or HA upon depletion of caveolin-1. Similar results were obtained using embryonic fibroblasts from caveolin-1-knockout mice. Thus, we conclude that caveolin-1 does not play a major role in lipid raft-mediated biosynthetic membrane trafficking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.