ArticleMolecular and cellular biology2005
The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination.Communications biology · 2026Article
- Article
- Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application ofInternational journal of molecular sciences · 2023Review
- Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes.Nature communications · 2021Article
- Loss of nucleosome remodelers CHRAC/ACF does not sensitize earlymicroPublication biology · 2020Article
- Computational Prediction of Intrinsic Disorder in Protein Sequences with the disCoP Meta-predictor.Methods in molecular biology (Clifton, N.J.) · 2020Article
- CHRAC/ACF contribute to the repressive ground state of chromatin.Life science alliance · 2018Article
- Article
- The Eukaryotic Replisome Goes Under the Microscope.Current biology : CB · 2016Review
- A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis.Developmental biology · 2016Article
- TheFrontiers in plant science · 2016Review
- The architecture of a eukaryotic replisome.Nature structural & molecular biology · 2015Article
- Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.The Journal of biological chemistry · 2015Article
- Genome-wide expression analysis of soybean NF-Y genes reveals potential function in development and drought response.Molecular genetics and genomics : MGG · 2015Article
- Arabidopsis DPB3-1, a DREB2A interactor, specifically enhances heat stress-induced gene expression by forming a heat stress-specific transcriptional complex with NF-Y subunits.The Plant cell · 2014Article
- Quantitative determination of binding of ISWI to nucleosomes and DNA shows allosteric regulation of DNA binding by nucleotides.Biochemistry · 2014Article
- Regulation of ISWI chromatin remodelling activity.Chromosoma · 2014Review
- Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ.Nature structural & molecular biology · 2014Article
- Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.PLoS genetics · 2013Article
- The promiscuous life of plant NUCLEAR FACTOR Y transcription factors.The Plant cell · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromatin accessibility complex (CHRAC) is an abundant, evolutionarily conserved nucleosome remodeling machinery able to catalyze histone octamer sliding on DNA. CHRAC differs from the related ACF complex by the presence of two subunits with molecular masses of 14 and 16 kDa, whose structure and function were not known. We determined the structure of Drosophila melanogaster CHRAC14-CHRAC16 by X-ray crystallography at 2.4-angstroms resolution and found that they dimerize via a variant histone fold in a typical handshake structure. In further analogy to histones, CHRAC14-16 contain unstructured N- and C-terminal tail domains that protrude from the handshake structure. A dimer of CHRAC14-16 can associate with the N terminus of ACF1, thereby completing CHRAC. Low-affinity interactions of CHRAC14-16 with DNA significantly improve the efficiency of nucleosome mobilization by limiting amounts of ACF. Deletion of the negatively charged C terminus of CHRAC16 enhances DNA binding 25-fold but leads to inhibition of nucleosome sliding, in striking analogy to the effect of the DNA chaperone HMGB1 on nucleosome sliding. The presence of a surface compatible with DNA interaction and the geometry of an H2A-H2B heterodimer may provide a transient acceptor site for DNA dislocated from the histone surface and therefore facilitate the nucleosome remodeling process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.