ArticleMolecular and cellular biology2005
Scavenger decapping activity facilitates 5' to 3' mRNA decay.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- RNA Metabolism and the Role of Small RNAs in Regulating Multiple Aspects of RNA Metabolism.Non-coding RNA · 2024Review
- Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex.Nucleic acids research · 2023Article
- mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- DcpS is a transcript-specific modulator of RNA in mammalian cells.RNA (New York, N.Y.) · 2015Article
- Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.Human molecular genetics · 2015Article
- Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.Human molecular genetics · 2015Article
- Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.Nucleic acids research · 2015Article
- Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae.PloS one · 2014Article
- The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.Molecular cell · 2013Article
- 7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.Biochemistry · 2012Article
- Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.RNA (New York, N.Y.) · 2012Article
- RNA degradation in Saccharomyces cerevisae.Genetics · 2012Review
- Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- DcpS as a therapeutic target for spinal muscular atrophy.ACS chemical biology · 2008Article
- Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.The Journal of biological chemistry · 2008Article
- DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.RNA (New York, N.Y.) · 2008Article
- Regulation of mRNA decapping.Wiley interdisciplinary reviews. RNAReview
- XRN 5'→3' exoribonucleases: structure, mechanisms and functions.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7GpppN cap dinucleotide, which is subsequently hydrolyzed to m7Gp and ppN in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p. Although Dcs1p functions in the last step of mRNA turnover, we demonstrate that its activity modulates earlier steps of mRNA decay. Disruption of the DCS1 gene manifests a threefold increase of the TIF51A mRNA half-life. Interestingly, the hydrolytic activity of Dcs1p was essential for the altered mRNA turnover, as Dcs1p, but not a catalytically inactive Dcs1p mutant, complemented the increased mRNA stability. Mechanistic analysis revealed that 5' to 3' exoribonucleolytic activity was impeded in the dcs1Delta strain, resulting in the accumulation of uncapped mRNA. These data define a new role for the Dcs1p scavenger decapping enzyme and demonstrate a novel mechanism whereby the final step in the 3' mRNA decay pathway can influence 5' to 3' exoribonucleolytic activity.
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Registered trials
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