ArticleNucleic acids research2005
Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Review
- Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase fromInternational journal of molecular sciences · 2023Article
- Human RecQ Helicases in DNA Double-Strand Break Repair.Frontiers in cell and developmental biology · 2021Review
- The RECQL helicase prevents replication fork collapse during replication stress.Life science alliance · 2020Article
- Factors affecting template switch recombination associated with restarted DNA replication.eLife · 2019Article
- Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients.BMC cancer · 2018Article
- RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.Biochemical Society transactions · 2018Review
- RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.The Biochemical journal · 2015Article
- Replication fork reversal in eukaryotes: from dead end to dynamic response.Nature reviews. Molecular cell biology · 2015Review
- Human RecQ helicases in DNA repair, recombination, and replication.Annual review of biochemistry · 2014Review
- RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Frontiers in genetics · 2014Review
- Solution small angle X-ray scattering (SAXS) studies of RecQ from Deinococcus radiodurans and its complexes with junction DNA substrates.The Journal of biological chemistry · 2013Article
- Roles of DNA helicases in the mediation and regulation of homologous recombination.Advances in experimental medicine and biology · 2013Article
- RecQ helicases in DNA double strand break repair and telomere maintenance.Mutation research · 2012Review
- Article
- RecQ helicases; at the crossroad of genome replication, repair, and recombination.Molecular biology reports · 2012Review
- An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.The EMBO journal · 2010Article
- The RecQ DNA helicases in DNA repair.Annual review of genetics · 2010Review
- RecQ helicases: multifunctional genome caretakers.Nature reviews. Cancer · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Homologous recombination provides an effective way to repair DNA double-strand breaks (DSBs) and is required for genetic recombination. During the process of homologous recombination, a heteroduplex DNA structure, or a 'Holliday junction' (HJ), is formed. The movement, or branch migration, of this junction is necessary for recombination to proceed correctly. In prokaryotes, the RecQ protein or the RuvA/RuvB protein complex can promote ATP-dependent branch migration of Holliday junctions. Much less is known about the processing of Holliday junctions in eukaryotes. Here, we identify RecQL1 as a predominant ATP-dependent, HJ branch migrator present in human nuclear extracts. A reduction in the level of RecQL1 induced by RNA interference in HeLa cells leads to an increase in sister chromatid exchange. We propose that RecQL1 is involved in the processing of Holliday junctions in human cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.