ReviewNeurotoxicity research2005
Molecular and cellular mechanisms of neuronal cell death in HIV dementia.
Review in Neurotoxicity research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed.
- Investigating how HIV-1 antiretrovirals differentially behave as substrates and inhibitors of P-glycoprotein via molecular dynamics simulations.Computational and structural biotechnology journal · 2024Article
- Sociodemographic Characteristics of HIV-Associated Dementia in the South Carolina Alzheimer's Disease Registry.Southern medical journal · 2023Article
- Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Emerging Role of Nef in the Development of HIV Associated Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Review
- The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection.Frontiers in microbiology · 2020Review
- Characterization of Nef expression in different brain regions of SIV-infected macaques.PloS one · 2020Article
- Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy.AIDS (London, England) · 2018Article
- Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study.Journal of neurovirology · 2018Article
- HIV-1 gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological Disorders.Neurotoxicity research · 2016Article
- The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons.Neurotoxicity research · 2016Article
- HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment.Nature reviews. Neurology · 2016Review
- Interaction of paroxetine with mitochondrial proteins mediates neuroprotection.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Article
- HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.Frontiers in microbiology · 2015Article
- Article
- Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.Current HIV research · 2015Review
- Neuroprotective activity of pDING in response to HIV-1 Tat.Journal of cellular physiology · 2014Article
- Heme oxygenase-1 dysregulation in the brain: implications for HIV-associated neurocognitive disorders.Current HIV research · 2014Review
- Apolipoprotein E-dependent differences in innate immune responses of maturing human neuroepithelial progenitor cells exposed to HIV-1.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neurotoxins include the HIV-1 proteins Tat and gp120, as well as pro-inflammatory cytokines, chemokines, excitotoxins and proteases. In this article we review the evidence for apoptosis of various cell types within the brain of HIV-infected patients, and describe in vitro and in vivo experimental studies that have elucidated the mechanisms by which HIV causes apoptosis of brain cells.
Indexed as
Identifiers
16260390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.