ArticlePharmaceutical research2005
ATP-loaded liposomes effectively protect the myocardium in rabbits with an acute experimental myocardial infarction.
Article in Pharmaceutical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Engineered ATP-loaded extracellular vesicles: a dual-functional strategy for improving myocardial infarction therapy.Drug delivery and translational research · 2026Article
- FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure.Journal of cardiovascular translational research · 2024Article
- Nanostructured Polymeric, Liposomal and Other Materials to Control the Drug Delivery for Cardiovascular Diseases.Pharmaceutics · 2020Review
- The interstitium in cardiac repair: role of the immune-stromal cell interplay.Nature reviews. Cardiology · 2018Review
- Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles.International journal of nanomedicine · 2017Article
- Micro- and Nanoparticles for Treating Cardiovascular Disease.Biomaterials science · 2015Article
- Targeting delivery of Radix Ophiopogonis polysaccharide to ischemic/reperfused rat myocardium by long-circulating macromolecular and liposomal carriers.International journal of nanomedicine · 2015Article
- Increased cardiac distribution of mono-PEGylated Radix Ophiopogonis polysaccharide in both myocardial infarction and ischemia/reperfusion rats.International journal of nanomedicine · 2015Article
- Single intracoronary injection of encapsulated antagomir-92a promotes angiogenesis and prevents adverse infarct remodeling.Journal of the American Heart Association · 2014Article
- Maintenance of ischemic β cell viability through delivery of lipids and ATP by targeted liposomes.Biomaterials science · 2014Article
- Administration of exogenous adenosine triphosphate to ischemic skeletal muscle induces an energy-sparing effect: role of adenosine receptors.The Journal of surgical research · 2013Article
- Internalization of paramagnetic phosphatidylserine-containing liposomes by macrophages.Journal of nanobiotechnology · 2012Article
- Liposomes in diagnosis and treatment of cardiovascular disorders.Methodist DeBakey cardiovascular journal · 2012Review
- Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles.International journal of nanomedicine · 2012Article
- Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury.Molecular vision · 2010Article
- Delivering regenerative cues to the heart: cardiac drug delivery by microspheres and peptide nanofibers.Journal of cardiovascular translational research · 2010Review
- Targeting ischemic penumbra: part I - from pathophysiology to therapeutic strategy.Journal of experimental stroke & translational medicine · 2010Article
- Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti-myosin antibody and TAT peptide.Gene therapy · 2009Article
- Protective effect of coenzyme Q10-loaded liposomes on the myocardium in rabbits with an acute experimental myocardial infarction.Pharmaceutical research · 2007Article
- "Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes.Journal of liposome research · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe assessed whether the infusion of ATP-loaded liposomes (ATP-L) can limit the fraction of the irreversibly damaged myocardium in rabbits with an experimental myocardial infarction.
methodsATP-L, empty liposomes (EL), or Krebs-Henseleit (KH) buffer were administered by intracoronary infusion, followed by 30 min of occlusion and 3 h of reperfusion. Unisperse Blue dye was used to demarcate the net size of the occlusion-induced ischemic zone (area at risk) and nitroblue tetrazolium staining was used to detect the final fraction of the irreversibly damaged myocardium within the total area at risk.
resultsThe total size of the area at risk in all experimental animals was approx. 20% wt. of the left ventricle. The final irreversible damage in ATP-L-treated animals was only ca. 30% of the total area at risk as compared with ca. 60% in the group treated with EL (p < 0.009) and ca. 70% in the KH buffer-treated group (p < 0.003).
conclusionsATP-L effectively protected the ischemic heart muscle in rabbits with an experimental myocardial infarction as evidenced by a significantly decreased fraction of the irreversibly damaged heart within the total area at risk. ATP-L may provide an effective exogenous source of the ATP in vivo to protect ischemically damaged cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.