Evidence map›Paper›PMID 16258194›Full record

ArticleMediators of inflammation2005

Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity.

Ozer Arican, Murat Aral, Sezai Sasmaz, Pinar Ciragil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 5 syntheses or guidelines pooled it, 783 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  8. Depletion of LAG-3Clinical pharmacology and therapeutics · 2021
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  15. CEACAM5 drives psoriatic inflammation by regulating CD8Biochemistry and biophysics reports · 2026
    Article
  16. Review
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  18. Review
  19. Psychopharmacology in Dermatology.Indian dermatology online journal · 2026
    Article
  20. Article

266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ozer AricanDepartment of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Turkey. ozerari@hotmail.com
Murat Aral
Sezai Sasmaz
Pinar Ciragil
Kahramanmaraş Sütçü İmam University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-gamma, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IFN-gamma, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity.

Indexed as

AdolescentAdultAgedBiomarkersCase-Control StudiesChildEnzyme-Linked Immunosorbent AssayFemaleHumansInterferon-gammaInterleukinsMaleMiddle AgedPsoriasisReference ValuesSeverity of Illness IndexBiomarkersInterferon-gammaInterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID16258194
PMCPMC1533889
OpenAlexW2112006696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.