ArticleBiophysical journal2006
Stimulation of actin polymerization by filament severing.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- The interaction ofMicrobiology (Reading, England) · 2020Article
- MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics.Oncotarget · 2016Article
- PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling.The EMBO journal · 2016Article
- Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.Frontiers in immunology · 2016Review
- Geometrical and mechanical properties control actin filament organization.PLoS computational biology · 2015Article
- Feedback mechanisms in a mechanical model of cell polarization.Physical biology · 2014Article
- Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model.BMC systems biology · 2014Article
- Modeling the synergy of cofilin and Arp2/3 in lamellipodial protrusive activity.Biophysical journal · 2013Article
- Competitive displacement of cofilin can promote actin filament severing.Biochemical and biophysical research communications · 2013Article
- There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.Biophysical journal · 2013Review
- Stoichiometry of Nck-dependent actin polymerization in living cells.The Journal of cell biology · 2012Article
- The interaction of cofilin with the actin filament.Journal of molecular biology · 2011Article
- Cofilin-linked changes in actin filament flexibility promote severing.Biophysical journal · 2011Article
- Robust organizational principles of protrusive biopolymer networks in migrating living cells.PloS one · 2011Article
- Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover.Biophysical journal · 2010Article
- Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Actin dynamics: from nanoscale to microscale.Annual review of biophysics · 2010Review
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- An open model of actin dendritic nucleation.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent and dynamics of actin polymerization in solution are calculated as functions of the filament severing rate, using a simple model of in vitro polymerization. The model is solved by both analytic theory and stochastic-growth simulation. The results show that severing essentially always enhances actin polymerization by freeing up barbed ends, if barbed-end cappers are present. Severing has much weaker effects if only pointed-end cappers are present. In the early stages of polymerization, the polymerized-actin concentration grows exponentially as a function of time. The exponential growth rate is given in terms of the severing rate, and the latter is given in terms of the maximum slope in a polymerization time course. Severing and branching are found to act synergistically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.