ArticleNucleic acids research2005
A method to find tissue-specific novel sites of selective adenosine deamination.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development.Cell reports · 2022Article
- Robust Acquisition of Spatial Transcriptional Programs in Tissues With Immunofluorescence-Guided Laser Capture Microdissection.Frontiers in cell and developmental biology · 2022Article
- To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis.Critical reviews in biochemistry and molecular biology · 2021Review
- Mapping the dsRNA World.Cold Spring Harbor perspectives in biology · 2019Review
- ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.Nucleic acids research · 2017Article
- Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.The Journal of biological chemistry · 2017Article
- Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage.RNA (New York, N.Y.) · 2013Article
- Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment.The Journal of biological chemistry · 2012Article
- Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.Current topics in microbiology and immunology · 2012Review
- Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.Nature chemical biology · 2010Article
- A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins.BMC bioinformatics · 2010Article
- Large-scale mRNA sequencing determines global regulation of RNA editing during brain development.Genome research · 2009Article
- An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme.RNA (New York, N.Y.) · 2009Article
- O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma.Oncogene · 2009Article
- Screening of human SNP database identifies recoding sites of A-to-I RNA editing.RNA (New York, N.Y.) · 2008Article
- Editing modifies the GABA(A) receptor subunit alpha3.RNA (New York, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Site-selective adenosine (A) to inosine (I) RNA editing by the ADAR enzymes has been found in a variety of metazoan from fly to human. Here we describe a method to detect novel site-selective A to I editing that can be used on various tissues as well as species. We have shown previously that there is a preference for ADAR2-binding to selectively edited sites over non-specific interactions with random sequences of double-stranded RNA. The method utilizes immunoprecipitation (IP) of intrinsic RNA-protein complexes to extract substrates subjected to site-selective editing in vivo, in combination with microarray analyses of the captured RNAs. We show that known single sites of A to I editing can be detected after IP using an antibody against the ADAR2 protein. The RNA substrates were verified by RT-PCR, RNase protection and microarray. Using this method it is possible to uniquely identify novel single sites of selective A to I editing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.