ArticleRespiratory research2005
The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.
Article in Respiratory research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Pulmonary surfactant protein D reduces lung cancer progression associated with decreased IL-4/STAT6 signaling.NPJ precision oncology · 2026Article
- Minilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract.Microbiology spectrum · 2022Article
- Mechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques.Journal of inflammation research · 2022Review
- Article
- Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.Mucosal immunology · 2016Article
- Article
- Pneumococci: immunology of the innate host response.Respirology (Carlton, Vic.) · 2010Review
- [Importance of surfactant proteins B and D for the differential diagnosis of acute dyspnea].Medizinische Klinik (Munich, Germany : 1983) · 2010Article
- Recent advances in alveolar biology: evolution and function of alveolar proteins.Respiratory physiology & neurobiology · 2010Review
- Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.Immunology · 2010Article
- Pulmonary surfactant: an immunological perspective.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Review
- Differential contribution of bacterial N-formyl-methionyl-leucyl- phenylalanine and host-derived CXC chemokines to neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia.Infection and immunity · 2007Article
- Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice.Respiratory research · 2007Article
- Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant.Respiratory research · 2007Article
- Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice.Infection and immunity · 2007Article
- Lung infections and innate host defense.Drug discovery today. Disease mechanisms · 2007Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S. pneumoniae was investigated in vivo, by comparing the outcome of intranasal infection in surfactant protein D deficient (SP-D-/-) to wildtype mice (SP-D+/+). Deficiency of SP-D was associated with enhanced colonisation and infection of the upper and lower respiratory tract and earlier onset and longer persistence of bacteraemia. Recruitment of neutrophils to inflammatory sites in the lung was similar in both strains mice in the first 24 hrs post-infection, but different by 48 hrs. T cell influx was greatly enhanced in SP-D-/- mice as compared to SP-D+/+ mice. Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.