ReviewThe Journal of comparative neurology2005
Forebrain substrates of reward and motivation.
Review in The Journal of comparative neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dopamine agonists for the treatment of cocaine dependence.The Cochrane database of systematic reviews · 2015Pooled it
- Elevated reward response to receipt of palatable food predicts future weight variability in healthy-weight adolescents.The American journal of clinical nutrition · 2017Trial
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Impact of Cesarean Delivery on Reward Behavior and Tyrosine Hydroxylase in the Nucleus Accumbens of Adult Prairie Vole Offspring.Developmental psychobiology · 2026Article
- The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential.Brain sciences · 2025Review
- Examining the role of the photopigment melanopsin in the striatal dopamine response to light.Frontiers in systems neuroscience · 2025Article
- Potential effect of antidepressants on remission from cocaine use disorder - A nationwide matched retrospective cohort study.Drug and alcohol dependence · 2023Article
- Mechanisms and consequences of weight gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease.Scientific reports · 2023Article
- Brain structure and working memory adaptations associated with maturation and aging in mice.Frontiers in aging neuroscience · 2023Article
- Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids.Journal of personalized medicine · 2022Review
- The Role of Intra-Amygdaloid Neurotensin and Dopamine Interaction in Spatial Learning and Memory.Biomedicines · 2022Article
- Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice.Psychopharmacology · 2022Article
- Inhibition of PSD95-nNOS protein-protein interactions decreases morphine reward and relapse vulnerability in rats.Addiction biology · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases asBrain sciences · 2022Article
- Encore: Behavioural animal models of stress, depression and mood disorders.Frontiers in behavioral neuroscience · 2022Review
- Ghrelin and the Control of Energy Balance in Females.Frontiers in endocrinology · 2022Review
- On the Similarity Between the Reinforcing and the Discriminative Properties of Intracranial Self-Stimulation.Frontiers in behavioral neuroscience · 2022Article
- Caffeine, genetic variation and anaerobic performance in male athletes: a randomized controlled trial.European journal of applied physiology · 2021Article
- Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion.Neuropharmacology · 2021Review
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Electrical stimulation of the medial forebrain bundle can reward arbitrary acts or motivate biologically primitive, species-typical behaviors like feeding or copulation. The subsystems involved in these behaviors are only partially characterized, but they appear to transsynaptically activate the mesocorticolimbic dopamine system. Basal function of the dopamine system is essential for arousal and motor function; phasic activation of this system is rewarding and can potentiate the effectiveness of reward-predictors that guide learned behaviors. This system is phasically activated by most drugs of abuse and such activation contributes to the habit-forming actions of these drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.