ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2005
The last common ancestor: what's in a name?
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- A new LUCApedia database for data-driven research on early evolutionary history.Bioinformatics advances · 2026Article
- The Unfinished Reconstructed Nature of the Last Universal Common Ancestor.Journal of molecular evolution · 2024Review
- The Last Universal Common Ancestor of Ribosome-Encoding Organisms: Portrait of LUCA.Journal of molecular evolution · 2024Review
- Volatile Organic Compound Metabolism on Early Earth.Journal of molecular evolution · 2024Article
- Evolution of Cellular Organization Along the First Branches of the Tree of Life.Journal of molecular evolution · 2024Article
- RNA or DNA? Revisiting the Chemical Nature of the Cenancestral Genome.Journal of molecular evolution · 2024Article
- On the Nature of the Last Common Ancestor: A Story from its Translation Machinery.Journal of molecular evolution · 2024Review
- Theoretical perspective on synthetic man-made life: Learning from the origin of life.Quantitative biology (Beijing, China) · 2023Review
- Pangenomic Analysis of Nucleo-Cytoplasmic Large DNA Viruses. I: The Phylogenetic Distribution of Conserved Oxygen-Dependent Enzymes Reveals a Capture-Gene Process.Journal of molecular evolution · 2023Article
- Ancestry of RNA/RNA interaction regions within segmented ribosomes.RNA (New York, N.Y.) · 2023Article
- How to build a protoribosome: structural insights from the first protoribosome constructs that have proven to be catalytically active.RNA (New York, N.Y.) · 2023Article
- A Short Tale of the Origin of Proteins and Ribosome Evolution.Microorganisms · 2022Review
- A consensus view of the proteome of the last universal common ancestor.Ecology and evolution · 2022Article
- Scaling laws in enzyme function reveal a new kind of biochemical universality.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- RNP-world: The ultimate essence of life is a ribonucleoprotein process.Genetics and molecular biology · 2022Article
- The Peptidyl Transferase Center: a Window to the Past.Microbiology and molecular biology reviews : MMBR · 2021Article
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
- Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Emerging Frontiers in the Study of Molecular Evolution.Journal of molecular evolution · 2020Article
- A Proposal of the Ur-proteome.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty completely sequenced cellular genomes from the three major domains were analyzed using twice one-way BLAST searches in order to define the set of the most conserved protein-encoding sequences to characterize the gene complement of the last common ancestor of extant life. The resulting set is dominated by different putative ATPases, and by molecules involved in gene expression and RNA metabolism. DEAD-type RNA helicase and enolase genes, which are known to be part of the RNA degradosome, are as conserved as many transcription and translation genes. This suggests the early evolution of a control mechanism for gene expression at the RNA level, providing additional support to the hypothesis that during early cellular evolution RNA molecules played a more prominent role. Conserved sequences related to biosynthetic pathways include those encoding putative phosphoribosyl pyrophosphate synthase and thioredoxin, which participate in nucleotide metabolism. Although the information contained in the available databases corresponds only to a minor portion of biological diversity, the sequences reported here are likely to be part of an essential and highly conserved pool of proteins domains common to all organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.