ArticlePLoS genetics2005
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
Article in PLoS genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Exploring the role of gelsolin and high-density lipoproteins in autoimmune diseases: spotlight on rheumatoid arthritis and systemic lupus erythematosus.Oxford open immunology · 2026Review
- Metabolomic and proteomic stratification of equine osteoarthritis.Equine veterinary journal · 2025Article
- Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.Molecular therapy. Nucleic acids · 2023Article
- Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.Genome biology · 2021Article
- Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment.Journal of translational medicine · 2021Article
- Review
- Article
- Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis.Arthritis research & therapy · 2015Article
- Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.Osteoarthritis and cartilage · 2015Article
- The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease.Arthritis research & therapy · 2014Article
- Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis.BioMed research international · 2014Review
- A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis.PloS one · 2013Article
- Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.The Journal of experimental medicine · 2012Article
- Genomics and proteomics approaches to the study of cancer-stroma interactions.BMC medical genomics · 2010Article
- Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling.BMC proceedings · 2009Article
- Transcription profiling of rheumatic diseases.Arthritis research & therapy · 2009Review
- Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.Annals of the rheumatic diseases · 2007Review
- Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics.Arthritis research & therapy · 2006Article
Corrections and comments
- Erratum issuedKazunori, Waki [corrected to Waki, Kazunori]
Authors and funding
17 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its aetiology and pathogenesis remain poorly understood. To identify novel genes and/or cellular pathways involved in the pathogenesis of the disease, we utilized a well-recognized tumour necrosis factor-driven animal model of this disease and performed high-throughput expression profiling with subtractive cDNA libraries and oligonucleotide microarray hybridizations, coupled with independent statistical analysis. This twin approach was validated by a number of different methods in other animal models of arthritis as well as in human patient samples, thus creating a unique list of disease modifiers of potential therapeutic value. Importantly, and through the integration of genetic linkage analysis and Gene Ontology-assisted functional discovery, we identified the gelsolin-driven synovial fibroblast cytoskeletal rearrangements as a novel pathophysiological determinant of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.