ArticlePLoS pathogens2005
Low effective dispersal of asexual genotypes in heterogeneous landscapes by the endemic pathogen Penicillium marneffei.
Article in PLoS pathogens, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Multicenter Case-Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam.Emerging infectious diseases · 2025Article
- An Overlooked and Underrated Endemic Mycosis-Talaromycosis and the Pathogenic Fungus Talaromyces marneffei.Clinical microbiology reviews · 2023Review
- Global Analyses of Multi-Locus Sequence Typing Data Reveal Geographic Differentiation, Hybridization, and Recombination in theJournal of fungi (Basel, Switzerland) · 2023Article
- Predicting the Geographic Distribution of theThe American journal of tropical medicine and hygiene · 2020Article
- Epidemiology of fungal infections in China.Frontiers of medicine · 2018Review
- Review
- Article
- Asexual propagation of a virulent clone complex in a human and feline outbreak of sporotrichosis.Eukaryotic cell · 2015Article
- The cryptic sexual strategies of human fungal pathogens.Nature reviews. Microbiology · 2014Review
- Clinical and molecular epidemiology of veterinary blastomycosis in Wisconsin.BMC veterinary research · 2013Article
- Ecological niche modeling of Bacillus anthracis on three continents: evidence for genetic-ecological divergence?PloS one · 2013Article
- Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks.PLoS neglected tropical diseases · 2013Article
- Clonality despite sex: the evolution of host-associated sexual neighborhoods in the pathogenic fungus Penicillium marneffei.PLoS pathogens · 2012Article
- Ecological niche modelling of the Bacillus anthracis A1.a sub-lineage in Kazakhstan.BMC ecology · 2011Article
- Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population--an emerging outbreak in Australia.PloS one · 2011Article
- Common reservoirs for Penicillium marneffei infection in humans and rodents, China.Emerging infectious diseases · 2011Article
- A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi.Genome biology · 2011Article
- The evolution of sex: a perspective from the fungal kingdom.Microbiology and molecular biology reviews : MMBR · 2010Review
- Development and evaluation of loop-mediated isothermal amplification (LAMP) for the rapid diagnosis of Penicillium marneffei in archived tissue samples.FEMS immunology and medical microbiology · 2010Article
- Fungal sex and pathogenesis.Clinical microbiology reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Long-distance dispersal in microbial eukaryotes has been shown to result in the establishment of populations on continental and global scales. Such "ubiquitous dispersal" has been claimed to be a general feature of microbial eukaryotes, homogenising populations over large scales. However, the unprecedented sampling of opportunistic infectious pathogens created by the global AIDS pandemic has revealed that a number of important species exhibit geographic endemicity despite long-distance migration via aerially dispersed spores. One mechanism that might tend to drive such endemicity in the face of aerial dispersal is the evolution of niche-adapted genotypes when sexual reproduction is rare. Dispersal of such asexual physiological "species" will be restricted when natural habitats are heterogeneous, as a consequence of reduced adaptive variation. Using the HIV-associated endemic fungus Penicillium marneffei as our model, we measured the distribution of genetic variation over a variety of spatial scales in two host species, humans and bamboo rats. Our results show that, despite widespread aerial dispersal, isolates of P. marneffei show extensive spatial genetic structure in both host species at local and country-wide scales. We show that the evolution of the P. marneffei genome is overwhelmingly clonal, and that this is perhaps the most asexual fungus yet found. We show that clusters of genotypes are specific to discrete ecological zones and argue that asexuality has led to the evolution of niche-adapted genotypes, and is driving endemicity, by reducing this pathogen's potential to diversify in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.