Trial reportEuropean journal of clinical nutrition2005
The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study.
Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Impact of micronutrient dietary intake and status on intestinal zinc absorption in late middle-aged men: the ZENITH study.European journal of clinical nutrition · 2005Trial
- [A polylactic acid/hydroxyapatite/scholzite composite scaffold for promoting healing of osteoporotic bone defects in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Effect of Nano- and Microzinc Supplementation on the Mineral Composition of Bones of Rats with Induced Mammary Gland Cancer.Foods (Basel, Switzerland) · 2023Article
- The Localized Ionic Microenvironment in Bone Modelling/Remodelling: A Potential Guide for the Design of Biomaterials for Bone Tissue Engineering.Journal of functional biomaterials · 2023Review
- Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients.Therapeutic advances in musculoskeletal disease · 2023Review
- The associations between serum trace elements and bone mineral density in children under 3 years of age.Scientific reports · 2021Article
- Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases.Nutrients · 2020Review
- Changes of Bone-Related Minerals during Denosumab Administration in Post-Menopausal Osteoporotic Patients.Nutrients · 2017Article
- Cognitive impairment, genomic instability and trace elements.The journal of nutrition, health & aging · 2015Review
- Role of nutritional zinc in the prevention of osteoporosis.Molecular and cellular biochemistry · 2010Review
- Zinc intake and biochemical markers of bone turnover in type 1 diabetes.Diabetes care · 2008Article
- Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan.European journal of clinical nutrition · 2007Article
- Introduction to the ZENITH study and summary of baseline results.European journal of clinical nutrition · 2005Review
- Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal DiseasesReview
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects.
designUse of baseline data from a multicentre prospective zinc intervention (ZENITH) study.
settingCentres in France, Italy and Northern Ireland.
participantsA total of 387 healthy adults, aged 55-87 y.
methodsZinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC.
resultsZinc intake was negatively correlated with urinary Pyr and Dpyr (r = -0.298 and -0.304, respectively; P < 0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r = -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r = -0.090; P < 0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (beta = -0.124; P = 0.011).
conclusionsThere was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.