ArticleEuropean journal of clinical nutrition2005
Immune response in relation to zinc status, sex and antioxidant defence in Italian elderly population: the ZENITH study.
Article in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Zinc Supplementation Partially Reconstitutes Impaired Interferon-γ Production in the Elderly.International journal of molecular sciences · 2026Article
- Glutathione Peroxide and Glutathione to Disulfide Glutathione Ratio in Presbycusis: a Case-control Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- The stoichiometric transition from Zn6Cu1-metallothionein to Zn7-metallothionein underlies the up-regulation of metallothionein (MT) expression: quantitative analysis of MT-metal load in eye cells.The Journal of biological chemistry · 2012Article
- The immune system and the impact of zinc during aging.Immunity & ageing : I & A · 2009Article
- Dal water as weaning food: a common but inappropriate practice.Indian journal of pediatrics · 2007Article
- Introduction to the ZENITH study and summary of baseline results.European journal of clinical nutrition · 2005Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvaluation of some immune markers in Italian elderly population in relation to zinc status, gender and antioxidant defence.
designObservational study.
settingItalian population. SUBJECTS: Apparently healthy, free-living subjects, 56 men and 52 women, aged 70-85 y, enrolled in Italy.
methodsLymphocytes were unstimulated or stimulated with the mitogen phytohemoagglutinin (PHA). The proliferative capacity was measured as incorporation of [3H]-thymidine and reported as stimulation index (SI). Cytokine secretion by lymphocytes was determined by ELISA. The antioxidant enzyme activities were measured using commercial kits.
resultsDietary zinc intake, as well as zinc in serum, red blood cells and urine were on the normal range of values and did not show any difference between men and women. The proliferative response showed a high variability without significant differences between men and women. The amount of secreted pro- and anti-inflammatory cytokines was similar in men and women. No differences were found in the activity of antioxidant enzymes in lymphocytes, namely superoxide dismutase, glutathione peroxidase and catalase, between men and women. An association between SI and serum zinc level in men was found. SI resulted negatively correlated with interleukin (IL)-1beta (R2 = 0.036 and P = 0.012) and IL-10 (R2 = 0.34 and P = 0.040) only in men. IL-10 of PHA-stimulated lymphocytes was negatively correlated with red blood zinc in men (R2 = 0.41 and P = 0.008), while IL-10 of unstimulated and PHA-stimulated lymphocytes were negatively correlated with serum zinc in women (R2 = 0.38 and P = 0.020; R2 = 0.31 and P = 0.040, respectively). No correlation was observed between immune markers and antioxidant enzyme activities.
conclusionsOnly weak differences on immune response between men and women were observed. However, zinc status appears to have more influence on the ability of lymphocytes to proliferate in men than in women.
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