ArticleJournal of virology2005
An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 91 citations in OpenAlex.
- Fatal BK polyomavirus-associated pneumonia: report of two cases with literature review.BMC infectious diseases · 2023Review
- Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells.PLoS pathogens · 2023Article
- Single-Cell Transcriptome Identifies the Renal Cell Type Tropism of Human BK Polyomavirus.International journal of molecular sciences · 2023Article
- Heparan Sulfate and Sialic Acid in Viral Attachment: Two Sides of the Same Coin?International journal of molecular sciences · 2022Review
- Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.RSC chemical biology · 2022Article
- Advances in the development of entry inhibitors for sialic-acid-targeting viruses.Drug discovery today · 2021Review
- Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination.Viruses · 2020Review
- Microtubules in Polyomavirus Infection.Viruses · 2020Review
- Polyoma virus nephropathy in kidney transplantation.World journal of transplantation · 2017Review
- Biology of the BKPyV: An Update.Viruses · 2017Review
- BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies.Clinical microbiology reviews · 2017Review
- Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells.Virology · 2016Article
- Mechanisms of BK virus infection of renal cells and therapeutic implications.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Review
- Sialic Acid Receptors of Viruses.Topics in current chemistry · 2015Review
- Structural documentation of glycan epitopes: sequential mass spectrometry and spectral matching.Journal of the American Society for Mass Spectrometry · 2014Article
- JC polyomavirus (JCV) and monoclonal antibodies: friends or potential foes?Clinical & developmental immunology · 2013Review
- Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis.Journal of virology · 2012Article
- Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding.Biochemistry · 2012Article
- Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectin.Journal of virology · 2012Article
- Coxsackievirus A24 variant uses sialic acid-containing O-linked glycoconjugates as cellular receptors on human ocular cells.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BK virus (BKV) is a common human polyomavirus infecting >80% of the population worldwide. Infection with BKV is asymptomatic, but reactivation in renal transplant recipients can lead to polyomavirus-associated nephropathy. In this report, we show that enzymatic removal of alpha(2,3)-linked sialic acid from cells inhibited BKV infection. Reconstitution of asialo cells with alpha(2,3)-specific sialyltransferase restored susceptibility to infection. Inhibition of N-linked glycosylation with tunicamycin reduced infection, but inhibition of O-linked glycosylation did not. An O-linked-specific alpha(2,3)-sialyltransferase was unable to restore infection in asialo cells. Taken together, these data indicate that an N-linked glycoprotein containing alpha(2,3)-linked sialic acid is a critical component of the cellular receptor for BKV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.