ArticleBlood2006
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Phenotype as Agent for Epigenetic Inheritance.Biology · 2016Article
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- Life Is Simple-Biologic Complexity Is an Epiphenomenon.Biology · 2016Article
- On the Evolution of the Mammalian Brain.Frontiers in systems neuroscience · 2016Article
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- Evolution and Cell Physiology. 1. Cell signaling is all of biology.American journal of physiology. Cell physiology · 2013Review
- Interstitial lung diseases-can pathologists arrive at an etiology-based diagnosis? A critical update.Virchows Archiv : an international journal of pathology · 2013Review
- A cell-molecular approach predicts vertebrate evolution.Molecular biology and evolution · 2011Article
- Cell-cell signaling drives the evolution of complex traits: introduction-lung evo-devo.Integrative and comparative biology · 2009Article
- Lung evolution as a cipher for physiology.Physiological genomics · 2009Review
- What We Talk About When We Talk About Evolution.Cell communication insightsArticle
- On the evolution of development.Trends in developmental biologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Goodpasture syndrome is an autoimmune vascular disease associated with kidney and lung failure, with pathogenic circulating autoantibodies targeted to a set of discontinuous epitope sequences within the noncollagenous domain-1 (NC1) of the alpha3 chain of type IV collagen (alpha3(IV)NC1), the Goodpasture autoantigen. We demonstrate that basement membrane extracted NC1 domain preparations from Caenorhabditis elegans, Drosophila melanogaster, and Danio rerio do not bind Goodpasture autoantibodies, while Xenopus laevis, chicken, mouse and human alpha3(IV)NC1 domains bind autoantibodies. The alpha3(IV) chain is not present in C elegans and Drosophila melanogaster, but is first detected in the Danio rerio. Interestingly, native Danio rerio alpha3(IV)NC1 does not bind Goodpasture autoantibodies. Next, we cloned, sequenced, and generated recombinant Danio rerio alpha3(IV)NC1 domain. In contrast to recombinant human alpha3(IV)NC1 domain, there was complete absence of autoantibody binding to recombinant Danio rerio alpha3(IV)NC1. Three-dimensional molecular modeling from existing x-ray coordinates of human NC1 domain suggest that evolutionary alteration of electrostatic charge and polarity due to the emergence of critical serine, aspartic acid, and lysine residues, accompanied by the loss of asparagine and glutamine, contributes to the emergence of the 2 major Goodpasture epitopes on the human alpha3(IV)NC1 domain, as it evolved from the Danio rerio over 450 million years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.