ReviewBlood2006
Designer blood: creating hematopoietic lineages from embryonic stem cells.
Review in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 73 citations in OpenAlex.
- Differentiation of human induced pluripotent stem cells into erythroid cells.Stem cell research & therapy · 2020Review
- Medial HOXA genes demarcate haematopoietic stem cell fate during human development.Nature cell biology · 2016Article
- Platelet generation in vivo and in vitro.SpringerPlus · 2016Review
- [The induction and cryopreservation of erythroid progenitor cells derived from umbilical cord blood mononuclear cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2016Article
- Advances in cellular technology in the hematology field: What have we learned so far?World journal of stem cells · 2015Review
- Immunotherapy with pluripotent stem cell-derived dendritic cells.Seminars in immunopathology · 2011Review
- Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.Blood · 2011Article
- Experimental limitations using reprogrammed cells for hematopoietic differentiation.Journal of biomedicine & biotechnology · 2011Review
- Article
- Induced pluripotent stem cell-derived human platelets: one step closer to the clinic.The Journal of experimental medicine · 2010Review
- Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells.The International journal of developmental biology · 2010Review
- Autologous blood cell therapies from pluripotent stem cells.Blood reviews · 2010Review
- Article
- Article
- Generation of mesenchymal stromal cells from HOXB4-expressing human embryonic stem cells.Cytotherapy · 2009Article
- Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis.Experimental hematology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic stem (ES) cells exhibit the remarkable capacity to become virtually any differentiated tissue upon appropriate manipulation in culture, a property that has been beneficial for studies of hematopoiesis. Until recently, the majority of this work used murine ES cells for basic research to elucidate fundamental properties of blood-cell development and establish methods to derive specific mature lineages. Now, the advent of human ES cells sets the stage for more applied pursuits to generate transplantable cells for treating blood disorders. Current efforts are directed toward adapting in vitro hematopoietic differentiation methods developed for murine ES cells to human lines, identifying the key interspecies differences in biologic properties of ES cells, and generating ES cell-derived hematopoietic stem cells that are competent to repopulate adult hosts. The ultimate medical goal is to create patient-specific and generic ES cell lines that can be expanded in vitro, genetically altered, and differentiated into cell types that can be used to treat hematopoietic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.