Evidence map›Paper›PMID 16252921›Full record

ArticleJournal of natural products2005

Retinoylserine and retinoylalanine, natural products of the moth Trichoplusia ni.

Barbara Rogge, Yasuhiro Itagaki, Nathan Fishkin, Ester Levi, Ralph Rühl, San-San Yi, Koji Nakanishi, Ulrich Hammerling

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Barbara RoggeImmunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Yasuhiro Itagaki
Nathan Fishkin
Ester Levi
Ralph Rühl
San-San Yi
Koji Nakanishi
Ulrich Hammerling
Memorial Sloan Kettering Cancer Center · USUniversity of Potsdam · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Vision Sciences Training GrantT32EY013933 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Carol A. Mason, CAROL M TROY · 2001 to 2026
$5.3M
NOVEL RECEPTORS OF VITAMIN A IN THE CYTOPLASMR01CA089362 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HAMMERLING, ULRICH G · 2001 to 2008
$2.5M
STUDIES ON RHODOPSIN &AGE-RELATED MACULAR DEGENERATIONR01GM036564 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NAKANISHI, KOJI · 1986 to 2006
$2.4M
New Pathway of Vitamin A Action.R01DK069348 · NIDDK · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HAMMERLING, ULRICH G · 2005 to 2009
$1.7M
LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLSR01CA049933 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HAMMERLING, ULRICH G · 1989 to 2004
$1.4M
NCI NIH HHS CA08748NCI NIH HHS CA49933NCI NIH HHS CA89362NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA049933NCI NIH HHS R01 CA089362NEI NIH HHS EY13933-3NEI NIH HHS T32 EY013933NIDDK NIH HHS R01 DK069348NIGMS NIH HHS GM36564NIGMS NIH HHS R01 GM036564
6 · The paper itself

Abstract

Insect cells convert vitamin A into a number of retinoids that are evolutionarily conserved with those of mammalian cells. However, insect cells also produce additional natural retinoids. Namely, two retinoic acid peptides, N-trans-retinoylserine (1) and N-trans-retinoylalanine (2), have been isolated from a cell line of the common cabbage looper, Trichoplusia ni. These are the first examples of naturally occurring retinoic acid linked to amino acids through an amide bond; the amino acid moieties are depicted in the more common l-configuration, although the absolute configuration was not determined due to the minuscule sample amount.

Indexed as

AlanineAnimalsChromatographyMolecular StructureMothsSerineSpectrometry, Mass, Electrospray IonizationStereoisomerismTretinoinAlanineretinoylalanineretinoylserineSerineTretinoin

Identifiers

PMID16252921
PMCPMC2532592
OpenAlexW1972441051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.