ArticleBritish journal of cancer2005
Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pooled it
- Metastasis-related genomic aberrations and evolutionary trajectory in uveal melanoma.Experimental & molecular medicine · 2026Article
- Choroidal biopsies; a review and optimised approach.Eye (London, England) · 2023Review
- Genetics and RNA Regulation of Uveal Melanoma.Cancers · 2023Review
- Genetic Basis and Molecular Mechanisms of Uveal Melanoma Metastasis: A Focus on Prognosis.Frontiers in oncology · 2022Review
- Article
- Enucleated globes with choroidal melanoma: A retrospective histopathological study and correlation with cytogenetic profile in 2 eye centers.Annals of medicine and surgery (2012) · 2020Article
- Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role forClinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Characterization of luteinizing hormone-releasing hormone receptor type I (LH-RH-I) as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines.OncoTargets and therapy · 2018Article
- Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma.Oncology reports · 2017Article
- Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma.The British journal of ophthalmology · 2014Article
- A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Molecular pathology of uveal melanoma.Eye (London, England) · 2013Review
- The impact of selected factors on early diagnosis of multiple primary cancers in patients with uveal melanoma.Contemporary oncology (Poznan, Poland) · 2013Article
- Chromosome 3 status in uveal melanoma: a comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array.Investigative ophthalmology & visual science · 2012Article
- The genetics of uveal melanoma: an emerging framework for targeted therapy.Pigment cell & melanoma research · 2012Review
- Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model.Melanoma research · 2012Review
- Frequency, molecular pathology and potential clinical significance of partial chromosome 3 aberrations in uveal melanoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2011Article
- Genetics of uveal melanoma and cutaneous melanoma: two of a kind?Dermatology research and practice · 2010Article
- Oncogenic mutations in GNAQ occur early in uveal melanoma.Investigative ophthalmology & visual science · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Defining regions of genomic imbalance can identify genes involved in tumour development. Conventional cytogenetics has identified several nonrandom copy number alterations (CNA) in uveal melanomas (UVM), which include monosomy 3, chromosome 6 abnormalities and gain of 8q. To gain further insight into the CNAs and define the regions involved more precisely we analysed 18 primary UVMs using 1 Mb BAC microarray comparative genomic hybridisation (CGH). Our analysis showed that the most common genomic imbalances were 8q gain (78%), 6p gain (67%) and monosomy 3 (56%). Two distinct CGH profiles could be delineated on the basis of the chromosome 3 status. The most common genetic changes in monosomy 3 tumours, in our study, were gain of 8q11.21-q24.3, 6p25.1-p21.2, 21q21.2-q21.3 and 21q22.13-q22.3 and loss of 1p36.33-p34.3, 1p31.1-p21.2, 6q16.2-q25.3 and 8p23.3-p11.23. In contrast, disomy 3 tumours showed recurrent gains of only 6p25.3-p22.3 and 8q23.2-q24.3. Our approach allowed definition of the smallest overlapping regions of imbalance, which may be important in the development of UVM.
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Registered trials
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