ArticleGenome research2005
Large-scale recombination rate patterns are conserved among human populations.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans.Genome biology · 2022Article
- Accurate recombination estimation from pooled genotyping and sequencing: a case study on barley.BMC genomics · 2022Article
- Population-Specific Recombination Maps from Segments of Identity by Descent.American journal of human genetics · 2020Article
- Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
- Complexity of genetic mechanisms conferring nonuniformity of recombination in maize.Scientific reports · 2017Article
- Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex.Nature communications · 2016Article
- The Time Scale of Recombination Rate Evolution in Great Apes.Molecular biology and evolution · 2016Article
- High-density interspecific genetic maps of kiwifruit and the identification of sex-specific markers.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- The 8p23 inversion polymorphism determines local recombination heterogeneity across human populations.Genome biology and evolution · 2014Article
- A de novo 10.79 Mb interstitial deletion at 2q13q14.2 involving PAX8 causing hypothyroidism and mullerian agenesis: a novel case report and literature review.Molecular cytogenetics · 2014Article
- Distribution of recombination hotspots in the human genome--a comparison of computer simulations with real data.PloS one · 2013Article
- Recombination rates in admixed individuals identified by ancestry-based inference.Nature genetics · 2011Article
- Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.PloS one · 2011Article
- Recombinational landscape of porcine X chromosome and individual variation in female meiotic recombination associated with haplotypes of Chinese pigs.BMC genomics · 2010Article
- Genetic crossovers are predicted accurately by the computed human recombination map.PLoS genetics · 2010Article
- Contrasting methods of quantifying fine structure of human recombination.Annual review of genomics and human genetics · 2010Review
- Variation in patterns of human meiotic recombination.Genome dynamics · 2009Review
- Worldwide population differentiation at disease-associated SNPs.BMC medical genomics · 2008Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, most recombination events occur in a small fraction of the genome. These hotspots of recombination show considerable variation in intensity and/or location across species and, potentially, across human populations. On a larger scale, the patterns of recombination rates have been mostly investigated in individuals of European ancestry, and it remains unknown whether the results obtained can be directly applied to other human populations. Here, we investigate this question using genome-wide polymorphism data. We show that population recombination rates recapitulate a large part of the genetic map information, regardless of the population considered. We also show that the ratio of the population recombination rate estimate of two populations is overall constant along the chromosomes. These two observations support the hypothesis that large-scale recombination patterns are conserved across human populations. Local deviations from the overall pattern of conservation of the recombination rates can be used to select candidate regions with large polymorphic inversions or under local selection.
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