ArticleGenome research2005
Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Rapid evolution of cancer/testis genes on the X chromosome.BMC genomics · 2007Trial
- Review
- Highly Selective, CRISPR/Cas9-Mediated Isolation of Genes and Genomic Loci from Complex Genomes by TAR Cloning in Yeast.Current protocols · 2021Article
- The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma.Scientific reports · 2021Article
- ASPM predicts poor prognosis and regulates cell proliferation in bladder cancer.The Kaohsiung journal of medical sciences · 2020Article
- TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology.Molecular therapy. Methods & clinical development · 2019Review
- Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient.Oncotarget · 2018Article
- Leucine zipper, down regulated in cancer-1 gene expression in prostate cancer.Oncology letters · 2016Article
- Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Chromosoma · 2016Review
- Article
- Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast.Nucleic acids research · 2015Article
- A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.Nucleic acids research · 2014Article
- Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis.European journal of human genetics : EJHG · 2013Article
- Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.Genes, chromosomes & cancer · 2012Article
- Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families.BMC medical genetics · 2012Article
- NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene.BMC cancer · 2011Article
- Expression of SPANX proteins in normal prostatic tissue and in prostate cancer.European journal of histochemistry : EJH · 2010Article
- Sexy gene conversions: locating gene conversions on the X-chromosome.Nucleic acids research · 2009Article
- SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.Journal of genetics · 2009Article
- Sperm-derived SPANX-B is a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Genetic linkage studies indicate that germline variations in a gene or genes on chromosome Xq27-28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer overlies a region of approximately 750 kb containing five SPANX genes (SPANX-A1, -A2, -B, -C, and -D) encoding sperm proteins associated with the nucleus; their expression was also detected in a variety of cancers. SPANX genes are >95% identical and reside within large segmental duplications (SDs) with a high level of similarity, which confounds mutational analysis of this gene family by routine PCR methods. In this work, we applied transformation-associated recombination cloning (TAR) in yeast to characterize individual SPANX genes from prostate cancer patients showing linkage to Xq27-28 and unaffected controls. Analysis of genomic TAR clones revealed a dynamic nature of the replicated region of linkage. Both frequent gene deletion/duplication and homology-based sequence transfer events were identified within the region and were presumably caused by recombinational interactions between SDs harboring the SPANX genes. These interactions contribute to diversity of the SPANX coding regions in humans. We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster.
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