ArticleAntimicrobial agents and chemotherapy2005
CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 75 citations in OpenAlex.
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- Limited clonality but widespread plasmid sharing of ESBL-producingCurrent research in microbial sciences · 2025Article
- Fecal Carriage of Extended-Spectrum β-Lactamase-/AmpC-ProducingAntibiotics (Basel, Switzerland) · 2023Article
- Comparison of approaches for source attribution of ESBL-producing Escherichia coli in Germany.PloS one · 2022Article
- Burden, Antibiotic Resistance, and Clonality ofTropical medicine and infectious disease · 2021Article
- Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-ProducingMicroorganisms · 2021Article
- ESBL ProducingFrontiers in public health · 2021Article
- Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.The Journal of veterinary medical science · 2020Article
- Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world.Heliyon · 2020Review
- Article
- Genetic environment of OXA-2 beta-lactamase producing Gram-negative bacilli from a tertiary referral hospital.The Indian journal of medical research · 2015Article
- High rates of intestinal colonisation with fluoroquinolone-resistant ESBL-harbouring Enterobacteriaceae in hospitalised patients with antibiotic-associated diarrhoea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- First Report of OXA-4, an ESBL Isolated from Pseudomonas aeruginosa a South Indian Strain.Indian journal of microbiology · 2013Article
- The emergence and dissemination of CTX-M-producing Escherichia coli sequence type 131 causing community-onset bacteremia in Israel.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria.Critical reviews in microbiology · 2013Review
- Article
- A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone.Journal of clinical microbiology · 2012Article
- Characterization of two new CTX-M-25-group extended-spectrum β-lactamase variants identified in Escherichia coli isolates from Israel.PloS one · 2012Article
- Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China.PloS one · 2012Article
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5 authors at 2 institutions in 1 country.
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Abstract
The rate of occurrence of the extended-spectrum beta-lactamase (ESBL)-producing phenotype among Escherichia coli isolates in Tel Aviv is 12% (22). The aim of this study was to understand the molecular epidemiology of E. coli ESBL producers and to identify the ESBL genes carried by them. We studied 20 single-patient ESBL-producing E. coli clinical isolates. They comprised 11 distinct nonrelated pulsed-field gel electrophoresis (PFGE) genotypes: six isolates belonged to the same PFGE clone, four other clones included two isolates each, and six unrelated clones included only one isolate. All isolates produced various beta-lactamases with pIs ranging from 5.2 to 8.2, varying within similar PFGE clones. The most prevalent ESBL gene was bla(CTX-M); 16 isolates carried bla(CTX-M-2) and three carried a new ESBL gene designated bla(CTX-M-39). Three strains carried bla(SHV) (two bla(SHV-12) and one bla(SHV-5)), and two strains carried inhibitor-resistant ESBL genes, bla(TEM-33) and bla(TEM-30); 18 strains carried bla(TEM-1) and eight strains carried bla(OXA-2). Plasmid mapping and Southern blot analysis with a CTX-M-2 probe demonstrated that bla(CTX-M-2) is plasmid borne. The wide dissemination of ESBLs among E. coli isolates in our institution is partly related to clonal spread, but more notably to various plasmid-associated ESBL genes, occurring in multiple clones, wherein the CTX-M gene family appears almost uniformly. We report here a new CTX-M gene, designated bla(CTX-M-39), which revealed 99% homology with bla(CTX-M-26), with a substitution of arginine for glutamine at position 225.
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