ArticleProceedings of the National Academy of Sciences of the United States of America2005
Adhesion controls bacterial actin polymerization-based movement.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Leading edge maintenance in migrating cells is an emergent property of branched actin network growth.eLife · 2022Article
- Processive acceleration of actin barbed-end assembly by N-WASP.Molecular biology of the cell · 2014Article
- Control of actin-based motility through localized actin binding.Physical biology · 2013Article
- Measuring forces at the leading edge: a force assay for cell motility.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Choosing orientation: influence of cargo geometry and ActA polarization on actin comet tails.Molecular biology of the cell · 2012Article
- Actin filament attachments for sustained motility in vitro are maintained by filament bundling.PloS one · 2012Article
- Motor-substrate interactions in mycoplasma motility explains non-Arrhenius temperature dependence.Biophysical journal · 2009Article
- Force-velocity relation for actin-polymerization-driven motility from Brownian dynamics simulations.Biophysical journal · 2009Article
- An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility.PLoS computational biology · 2009Article
- Force amplification response of actin filaments under confined compression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Models for actin polymerization motors.Journal of mathematical biology · 2009Review
- Curvature and torsion in growing actin networks.Physical biology · 2008Article
- Load fluctuations drive actin network growth.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A kinematic description of the trajectories of Listeria monocytogenes propelled by actin comet tails.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains.Cell · 2007Article
- VASP governs actin dynamics by modulating filament anchoring.Biophysical journal · 2007Article
- Diffusion rate limitations in actin-based propulsion of hard and deformable particles.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As part of its infectious life cycle, the bacterial pathogen Listeria monocytogenes propels itself through the host-cell cytoplasm by triggering the polymerization of host-cell actin near the bacterial surface, harnessing the activity of several cytoskeletal proteins used during actin-based cell crawling. To distinguish among several classes of biophysical models of actin-based bacterial movement, we used a high-throughput tracking technique to record the movement of many individual bacteria during temperature shifts. The speed of each bacterium varied strongly with temperature, closely following the Arrhenius rate law. Among bacteria, the prefactor A of the Arrhenius dependence unexpectedly varied exponentially with apparent activation energy, E(a), over a wide range (8-21 kcal/mol), reminiscent of the "rate compensation effect" of classical catalytic reactions. Average E(a) were increased for mutant bacteria deficient in binding Ena/VASP proteins and bacteria moving in diluted extract. These two effects were additive. The observed temperature and rate compensation effects are consistent with a class of simple kinetic models in which the bacterium advances through the thermally driven, cooperative breakage of groups of adhesive bonds on its surface. The estimated number of coupled adhesive bonds N on the bacterial surface varies between 10 and 40 bonds. In contrast to other models, this model correctly predicts an experimentally observed negative correlation between bacterial speed and actin gel density. The idea that speed depends on adhesion, rather than polymerization, suggests several alternative mechanisms by which known cytoskeletal regulatory proteins could control cellular movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.