ArticleCardiovascular ultrasound2005
Dobutamine stress echocardiography in healthy adult male rats.
Article in Cardiovascular ultrasound, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.Cardiovascular research · 2023Article
- The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats.Experimental neurology · 2022Article
- Individual variability in animal-specific hemodynamic compensation following myocardial infarction.Journal of molecular and cellular cardiology · 2022Article
- Article
- Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy.Chinese medical journal · 2021Article
- Metoprolol ImpairsThe Journal of pharmacology and experimental therapeutics · 2021Article
- Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity.Scientific reports · 2018Article
- Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents.Physiological reports · 2018Article
- Challenging cardiac function post-spinal cord injury with dobutamine.Autonomic neuroscience : basic & clinical · 2018Review
- A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2017Article
- Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.Advanced healthcare materials · 2017Article
- Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats.BMC cardiovascular disorders · 2016Article
- GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.Circulation · 2012Article
- Dobutamine "stress" test and latent cardiac susceptibility to inhaled diesel exhaust in normal and hypertensive rats.Environmental health perspectives · 2012Article
- Placement of an elastic biodegradable cardiac patch on a subacute infarcted heart leads to cellularization with early developmental cardiomyocyte characteristics.Journal of cardiac failure · 2012Article
- Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac Myocytes.Biochemistry research international · 2012Article
- Echocardiographic evaluation of cardiac structure and function during exercise training in the developing Sprague-Dawley rat.Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure.American journal of physiology. Heart and circulatory physiology · 2010Article
- Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDobutamine stress echocardiography is used to investigate a wide variety of heart diseases in humans. Dobutamine stress echocardiography has also been used in animal models of heart disease despite the facts that the normal response of healthy rat hearts to this type of pharmacological stress testing is unknown. This study was performed to assess this normal response.
methods15 normal adult male Wistar rats were evaluated. Increasing doses of dobutamine were infused intravenously under continuous imaging of the heart by a 12 MHz ultrasound probe.
resultsDobutamine stress echocardiography reduced gradually LV diastolic and systolic dimensions. Ejection fraction increased by a mean of +24% vs. baseline. Heart rate increased progressively without reaching a plateau. Changes in LV dimensions and ejection fraction reached a plateau after a mean of 4 minutes at a constant infusion rate.
conclusionDSE can be easily performed in rats. The normal response is an increase in heart rate and ejection fraction and a decrease in LV dimensions. A plateau in echocardiographic measurements is obtained after 4 minutes of a constant infusion rate in most animals.
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